Calreticulin protects insulin against reductive stress in vitro and in MIN6 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochimie"
DOI: 10.1016/j.biochi.2020.01.011
Abstract: Oxidative folding of proinsulin in the endoplasmic reticulum (ER) is critical for the proper sorting and secretion of insulin from pancreatic β-cells. Here, by using non-cell-based insulin aggregation assays and mouse insulinoma-derived MIN6 cells, we… read more here.
Keywords: insulin; reductive stress; crt; min6 cells ... See more keywords
Reductive stress promotes protein aggregation and impairs neurogenesis
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DOI: 10.1016/j.redox.2020.101739
Abstract: Redox homeostasis regulates key cellular signaling in both physiology and pathology. While perturbations result in shifting the redox homeostasis towards oxidative stress are well documented, the influence of reductive stress (RS) in neurodegenerative diseases and… read more here.
Keywords: tau; redox; stress; protein aggregation ... See more keywords
Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium
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DOI: 10.1111/jpi.12806
Abstract: Melatonin (MLT) is a cytoprotective agent holding potential to prevent cadmium (Cd) toxicity and its impact in testicular function and fertility. In this study, we explored such potential in porcine pre‐pubertal Sertoli cells (SCs). Cd… read more here.
Keywords: reductive stress; activity; h2o2 generation; expression ... See more keywords
Abstract 539: Buthionine Sulfoximine (BSO) Prevents Reductive Stress-induced Pathological Hypertrophic Cardiomyopathy
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DOI: 10.1161/res.127.suppl_1.539
Abstract: Background: Chronic reductive stress (RS) induces pathological cardiac remodeling and diastolic dysfunction. Here, we hypothesized that preventing RS via glutathione (GSH) depletion, through selective inhibition of γ-glutamyl cysteine ligase (γGCL), mitigates cardiac pathology in cRS… read more here.
Keywords: bso; gsh; reductive stress; sulfoximine bso ... See more keywords
Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging
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DOI: 10.3390/antiox12051126
Abstract: This review is focused on the mechanisms that regulate health, disease and aging redox status, the signal pathways that counteract oxidative and reductive stress, the role of food components and additives with antioxidant properties (curcumin,… read more here.
Keywords: stress; stress antioxidants; oxidative stress; stress reductive ... See more keywords
Complexity of NAC Action as an Antidiabetic Agent: Opposing Effects of Oxidative and Reductive Stress on Insulin Secretion and Insulin Signaling
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DOI: 10.3390/ijms23062965
Abstract: Dysregulated redox balance is involved in the pathogenesis of type 2 diabetes. While the benefit of antioxidants in neutralizing oxidative stress is well characterized, the potential harm of antioxidant-induced reductive stress is unclear. The aim… read more here.
Keywords: stress; insulin secretion; insulin signaling; reductive stress ... See more keywords