Non-redundant functions of EMT transcription factors
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DOI: 10.1038/s41556-018-0196-y
Abstract: Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in… read more here.
Keywords: non redundant; emt transcription; emt tfs; redundant functions ... See more keywords
Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41116-1
Abstract: Adhesion signaling between epithelial cells and the extracellular matrix plays a critical role in maintaining tissue homeostasis and the response to tissue damage. Focal adhesion kinase (FAK) and its close relative Pyk2 are non-receptor tyrosine… read more here.
Keywords: non redundant; epithelial repair; redundant functions; colitis ... See more keywords
Unique and redundant functions of cytoplasmic actins and nonmuscle myosin II isoforms at epithelial junctions
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14808
Abstract: The integrity and functions of epithelial barriers depend on the formation of adherens junctions (AJs) and tight junctions (TJs). A characteristic feature of AJs and TJs is their association with the cortical cytoskeleton composed of… read more here.
Keywords: actin isoforms; redundant functions; myosin; unique redundant ... See more keywords
Mesenchymal Lineage Heterogeneity Underlies Non-Redundant Functions of Pancreatic Cancer-Associated Fibroblasts.
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DOI: 10.1158/2159-8290.cd-21-0601
Abstract: Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood. The abundant and transcriptionally diverse CAF population in pancreatic ductal adenocarcinoma (PDAC) is thought to arise… read more here.
Keywords: non redundant; cancer associated; redundant functions; cancer ... See more keywords