The effects of neonatal procedural pain and maternal isolation on hippocampal cell proliferation and reelin concentration in neonatal and adult male and female rats.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental psychobiology"
DOI: 10.1002/dev.22212
Abstract: Preterm births accounted for over 10% of all U.S. live births in 2019 and the rate is rising. Neonatal stressors, especially procedural pain, experienced by preterm infants in the neonatal intensive care unit (NICU) have… read more here.
Keywords: adult; procedural pain; proliferation; effects neonatal ... See more keywords
Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24688
Abstract: Axonal outgrowth is a fundamental process during the development of central (CNS) and peripheral (PNS) nervous system as well as in nerve regeneration and requires accurate axonal navigation and extension to the correct target. These… read more here.
Keywords: outgrowth; regeneration; drg neurons; dorsal root ... See more keywords
Purification of a heterodimeric Reelin construct to investigate binding stoichiometry
Sign Up to like & getrecommendations! Published in 2020 at "European Biophysics Journal"
DOI: 10.1007/s00249-020-01465-6
Abstract: Reelin is a secreted glycoprotein that is integral in neocortex development and synaptic function. Reelin exists as a homodimer with two chains linked by a disulfide bond at cysteine 2101, a feature that is vital… read more here.
Keywords: construct; stoichiometry; purification heterodimeric; reelin construct ... See more keywords
Roles of Reelin/Disabled1 pathway on functional recovery of hemiplegic mice after neural cell transplantation; Reelin promotes migration toward motor cortex and maturation to motoneurons of neural grafts
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.112970
Abstract: Reelin is a large glycoprotein which regulates central nervous system (CNS) development. Dysfunctions of Reelin were reported on certain neuropsychiatric diseases. We examined involvement of Reelin pathway in functional recovery of hemiplegic mice after neural… read more here.
Keywords: cortex; hemiplegic mice; functional recovery; transplantation ... See more keywords
Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2017.05.033
Abstract: OBJECTIVE The extracellular matrix protein reelin regulates early brain development and synaptic plasticity in adulthood. Reelin is decreased in the postmortem brain in schizophrenia patients. Reelin's two receptors, ApoER2 and VLDLR, are also substrates for… read more here.
Keywords: fatty acid; reelin expression; bipolar disorder; schizophrenia bipolar ... See more keywords
Specific contribution of Reelin expressed by Cajal–Retzius cells or GABAergic interneurons to cortical lamination
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120079119
Abstract: Significance The present study highlights a fundamental role of GABAergic interneuron-derived Reelin in neuronal migration, in addition to CR cell–expressed Reelin. Further, we observed transient migratory deficits, indicating that Reelin expressed by either neuronal population… read more here.
Keywords: reelin expressed; expressed cajal; reelin; lamination ... See more keywords
Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa088
Abstract: The glycoprotein Reelin maintains neuronal positioning and regulates neuronal plasticity in the adult brain. Reelin deficiency has been associated with neurological diseases. We recently showed that Reelin is depleted in mice with a targeted disruption… read more here.
Keywords: ca1 hippocampus; hippocampus; ndel1 cko; mice ... See more keywords
Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2017 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhv334
Abstract: Reelin-Dab1 signaling is involved in brain development and neuronal functions. The abnormalities in the signaling through either reduction of Reelin and Dab1 gene expressions or the genomic mutations in the brain have been reported to… read more here.
Keywords: reelin dab1; deficiency reelin; dorsal forebrain; psychiatric disorders ... See more keywords
Alterations in reelin and reelin receptors in Down syndrome
Sign Up to like & getrecommendations! Published in 2019 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001153
Abstract: Reelin is an extracellular matrix glycoprotein that modulates synaptic function and plasticity, with a crucial role in neuronal migration. Changes in the expression of this protein have been reported in neurodegenerative diseases, such as Alzheimer’s… read more here.
Keywords: mice; density; receptor; alterations reelin ... See more keywords
Fate tracking reveals differences between Reelin+ hepatic stellate cells (HSCs) and Desmin+ HSCs in activation, migration and proliferation.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13500
Abstract: The activation of hepatic stellate cells (HSCs) is the main cause of liver fibrogenesis in response to different etiologies of chronic liver injuries. HSCs are heterogeneous, but the lack of specific markers to distinguish different… read more here.
Keywords: hscs; liver; proliferation; reelin ... See more keywords
Reelin dorsal horn neurons co‐express Lmx1b and are mispositioned in disabled‐1 mutant mice
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14847
Abstract: Mice missing either Reelin or Disabled‐1 (Dab1) exhibit dorsal horn neuronal positioning errors and display heat hypersensitivity and mechanical insensitivity. Reelin binds its receptors, apolipoprotein E receptor 2 and very low‐density lipoprotein receptor, leading to… read more here.
Keywords: horn neurons; dorsal horn; lmx1b; reelin lmx1b ... See more keywords