Refinement of In Vitro Methods for Identification of Aldehyde Oxidase Substrates Reveals Metabolites of Kinase Inhibitors
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DOI: 10.1124/dmd.118.080960
Abstract: To identify aldehyde oxidase (AO) substrates, an assay procedure was developed that leverages the capabilities of high-resolution mass spectrometry to simultaneously monitor parent loss and formation of hydroxylated metabolite over time in incubations with liver… read more here.
Keywords: kinase inhibitors; metabolism; refinement vitro; aldehyde oxidase ... See more keywords