Basiliximab for steroid‐refractory acute graft‐versus‐host disease: A real‐world analysis
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DOI: 10.1002/ajh.26475
Abstract: Steroid‐refractory (SR) acute graft‐versus‐host disease (aGVHD) is one of the leading causes of early mortality after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). We investigated the efficacy, safety, prognostic factors, and optimal therapeutic protocol for SR‐aGVHD… read more here.
Keywords: basiliximab; steroid refractory; refractory acute; acute graft ... See more keywords
Safety and efficacy of a humanized CD19 chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic leukemia
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DOI: 10.1002/ajh.26506
Abstract: CD19‐targeted chimeric antigen receptor T (CAR‐T) cells using murine single‐chain variable fragment (scFv) has shown substantial clinical efficacy in treating relapsed/refractory acute lymphoblastic leukemia (R/R ALL). However, potential immunogenicity of the murine scFv domain may… read more here.
Keywords: antigen receptor; refractory acute; relapsed refractory; chimeric antigen ... See more keywords
Improved outcome of children with relapsed/refractory acute myeloid leukemia by addition of cladribine to re‐induction chemotherapy
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DOI: 10.1002/cam4.3681
Abstract: The preferred salvage treatment for children with relapsed/refractory acute myeloid leukemia (R/R‐AML) remains unclear. The combination of cladribine/Ara‐C/granulocyte‐colony stimulating factor and mitoxantrone (CLAG‐M) shown promising results in adult R/R‐AML. We aim to investigate the efficacy… read more here.
Keywords: relapsed refractory; children relapsed; refractory acute; myeloid leukemia ... See more keywords
Allogeneic hematopoietic cell transplantation for primary refractory acute lymphoblastic leukemia: A report from the Acute Leukemia Working Party of the EBMT
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DOI: 10.1002/cncr.30604
Abstract: Patients with primary refractory acute lymphoblastic leukemia (PREF ALL) who fail to achieve a complete remission (CR) after ≥2 courses of chemotherapy have a dismal prognosis without undergoing allogeneic hematopoietic cell transplantation (HCT). To the… read more here.
Keywords: acute; refractory acute; primary refractory; transplantation ... See more keywords
Dose, schedule, safety, and efficacy of guadecitabine in relapsed or refractory acute myeloid leukemia
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DOI: 10.1002/cncr.31138
Abstract: Outcomes for patients with relapsed or refractory acute myeloid leukemia (AML) are poor. Guadecitabine, a next‐generation hypomethylating agent, could be useful in treating such patients. read more here.
Keywords: relapsed refractory; refractory acute; myeloid leukemia; acute myeloid ... See more keywords
A phase 1b study of venetoclax and alvocidib in patients with relapsed/refractory acute myeloid leukemia.
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DOI: 10.1002/hon.3159
Abstract: Relapsed/refractory (R/R) Acute Myeloid Leukemia (AML) is a genetically complex and heterogeneous disease with a poor prognosis and limited treatment options. Thus, there is an urgent need to develop therapeutic combinations to overcome drug resistance… read more here.
Keywords: myeloid leukemia; refractory acute; relapsed refractory; alvocidib ... See more keywords
FLAG vs FLAG-IDA: outcomes in relapsed/refractory acute leukemias
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DOI: 10.1007/s00280-019-03792-8
Abstract: BackgroundFLAG (fludarabine, cytarabine, granulocyte colony—stimulating factor) and FLAG-IDA (idarubicin added to standard FLAG) are salvage chemotherapy regimens used for relapsed and refractory acute leukemias. The toxicity of the FLAG-IDA courses is generally more severe than… read more here.
Keywords: relapsed refractory; flag ida; refractory acute; remission ... See more keywords
Gilteritinib versus chemotherapy in Japanese patients with FLT3-mutated relapsed/refractory acute myeloid leukemia
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DOI: 10.1007/s10147-021-02006-7
Abstract: Until recently, no effective targeted therapies for FLT3-mutated (FLT3mut+) relapsed/refractory (R/R) acute myeloid leukemia (AML) were available in Japan. The FLT3 inhibitor, gilteritinib, was approved in Japan for patients with FLT3mut+ R/R AML based on… read more here.
Keywords: relapsed refractory; gilteritinib; refractory acute; myeloid leukemia ... See more keywords
Safety and pharmacokinetics of quizartinib in Japanese patients with relapsed or refractory acute myeloid leukemia in a phase 1 study
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02709-8
Abstract: Expanded therapeutic options are warranted for patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) who have FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutations. The present phase 1, multicenter, open-label, dose-escalation and dose-expansion… read more here.
Keywords: relapsed refractory; refractory acute; myeloid leukemia; study ... See more keywords
RNA Sequencing of Intestinal Biopsies Expands the T Cell-Centric Paradigm of Steroid-Refractory Acute Graft-Versus-Host Disease
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DOI: 10.1016/j.bbmt.2018.12.673
Abstract: Background Steroid-refractory acute GVHD (aGVHD) is a fatal disease with little known regarding its pathophysiology at the tissue level. We studied the gene expression profiles of onset and steroid-refractory aGVHD intestinal biopsies, including both supervised… read more here.
Keywords: intestinal biopsies; refractory acute; steroid refractory; cell ... See more keywords
Impact of minimal residual disease status in patients with relapsed/refractory acute lymphoblastic leukemia treated with inotuzumab ozogamicin in the phase III INO-VATE trial.
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia research"
DOI: 10.1016/j.leukres.2019.106283
Abstract: Minimal residual disease (MRD) negativity is a key prognostic indicator of outcome in acute lymphocytic leukemia. In the INO-VATE trial (clinicaltrials.gov identifier: NCT01564784), patients with relapsed/refractory acute lymphocytic leukemia who received inotuzumab versus standard chemotherapy… read more here.
Keywords: relapsed refractory; refractory acute; mrd negativity; patients relapsed ... See more keywords