RNA Sequencing of Intestinal Biopsies Expands the T Cell-Centric Paradigm of Steroid-Refractory Acute Graft-Versus-Host Disease
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.673
Abstract: Background Steroid-refractory acute GVHD (aGVHD) is a fatal disease with little known regarding its pathophysiology at the tissue level. We studied the gene expression profiles of onset and steroid-refractory aGVHD intestinal biopsies, including both supervised… read more here.
Keywords: intestinal biopsies; refractory acute; steroid refractory; cell ... See more keywords
REACH2: ruxolitinib for refractory aGvHD
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-020-0385-z
Abstract: (median 5 months versus 1 month; HR 0.46, 95% CI 0.35–0.60) and overall survival (median 11.1 months versus 6.5 months; HR 0.83, 95% CI 0.60–1.15) also favoured ruxolitinib. With regard to toxicity, increased day-28 rates… read more here.
Keywords: refractory agvhd; reach2 ruxolitinib; agvhd; ruxolitinib refractory ... See more keywords