The efficacy and safety of ganaxolone for the treatment of refractory epilepsy: A meta‐analysis from randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12669
Abstract: Epilepsy is one of the most common and refractory neurological disorders globally. Ganaxolone, a neuroactive steroid that enhances GABAergic inhibition, has been tested in many trials for the resolution of refractory epilepsy. Based on these,… read more here.
Keywords: ganaxolone; refractory; meta analysis; refractory epilepsy ... See more keywords
[Results of vagus nerve stimulator implantation in children and adolescents with treatment-refractory epilepsy].
Sign Up to like & getrecommendations! Published in 2022 at "HNO"
DOI: 10.1007/s00106-022-01164-y
Abstract: Vagus nerve stimulation (VNS) is a therapeutic procedure that can be applied in a palliative setting in patients with treatment-refractory epilepsy who are not suitable for epilepsy surgery. The mechanism of action of VNS is currently not… read more here.
Keywords: nerve stimulator; epilepsy; treatment refractory; vagus nerve ... See more keywords
Investigation of altered microstructure in patients with drug refractory epilepsy using diffusion tensor imaging
Sign Up to like & getrecommendations! Published in 2017 at "Neuroradiology"
DOI: 10.1007/s00234-017-1835-x
Abstract: PurposeThe risk of refractory epilepsy can be more dangerous than the adverse effect caused by medical treatment. In this study, we employed voxel-wise analysis (VWA) and tract-based spatial statistics (TBSS) methods to measure microstructural changes… read more here.
Keywords: dre patients; diffusion; refractory epilepsy;
Successful treatment of cannabinoid administration against refractory epilepsy in Batten disease: a case report
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04763-1
Abstract: Dear Editor, In recent years, the use of cannabinoids for therapeutic purposes has gained ground, particularly in CNS disorders [1]. We present a case with refractory epilepsy on the background of neuronal ceroid lipofuscinosis 6-syndrome… read more here.
Keywords: refractory epilepsy; treatment; per day; batten disease ... See more keywords
Association of ABCB1 gene polymorphism (C1236T and C3435T) with refractory epilepsy in Iraqi patients
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05540-1
Abstract: The mechanisms of refractory epilepsy (RE) are most likely multifactorial, involving environmental, genetic, as well as disease- and drug-related factors. We aimed to study is to investigate the possible association of two ABCB1 gene polymorphism… read more here.
Keywords: epilepsy; abcb1 gene; polymorphism; refractory epilepsy ... See more keywords
Frequency of menstrual abnormalities and their associated neuroimaging findings in women with focal refractory epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neurologica Belgica"
DOI: 10.1007/s13760-020-01374-7
Abstract: Patients with refractory epilepsy can suffer from psychological and physical problems. Epilepsy can also be associated with menstruation abnormalities in women. In this paper, we aim to survey women with focal refractory epilepsy who also… read more here.
Keywords: epilepsy; refractory epilepsy; pathology; women focal ... See more keywords
Successful hemispherotomy in two refractory epilepsy patients with cerebral hemiatrophy and contralateral EEG abnormalities
Sign Up to like & getrecommendations! Published in 2018 at "Brain and Development"
DOI: 10.1016/j.braindev.2018.02.014
Abstract: We describe two cases of refractory epilepsy with cerebral hemiatrophy and contralateral electroencephalographic (EEG) abnormalities, in which hemispherotomy of the atrophic hemisphere effectively controlled seizures. Case 1 was a 5-year-1-month-old girl with refractory bilateral asymmetrical… read more here.
Keywords: eeg; refractory epilepsy; patients cerebral; hemiatrophy contralateral ... See more keywords
F129. Detection and characteristics of temporal encephaloceles in patients with refractory epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2018.04.292
Abstract: Introduction Temporal encephaloceles (TEs) have recently garnered interest in patients with prior MRI-negative refractory temporal lobe epilepsy (RTLE) as a potential source of focality. Careful review by an experienced neuroradiologist may yield improved detection of… read more here.
Keywords: detection; refractory epilepsy; seizure onset; patients tes ... See more keywords
De-novo mutations in patients with chronic ultra-refractory epilepsy with onset after age five years.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2019.01.015
Abstract: We set out to investigate whether a de-novo paradigm could explain genetic causes of chronic ultra-refractory epilepsy, with onset later than the typical age for the epileptic encephalopathies. We performed exome sequencing on nine adult… read more here.
Keywords: epilepsy; refractory epilepsy; chronic ultra; novo mutations ... See more keywords
Refractory epilepsy associated with anti-ribosomal P antibodies successfully treated with topiramate
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2020.577144
Abstract: We report the case of a 25-year-old woman who developed temporal lobe epilepsy associated with systemic lupus erythematosus (SLE). Serum and cerebrospinal fluid samples showed high titers of anti-ribosomal P (anti-P) antibodies with negative anti-NMDAR… read more here.
Keywords: epilepsy; anti ribosomal; refractory epilepsy; associated anti ... See more keywords
Effect of zonisamide on refractory epilepsy during pregnancy in lamotrigine resistant kindled rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.11.020
Abstract: Drug-resistant epilepsy with uncontrolled severe seizures despite state-of-the-art medical treatment continues to be a major clinical problem. Pregnancy is a state where drug pharmacokinetic changes are more pronounced and more rapid than any other period… read more here.
Keywords: epilepsy; pregnancy; refractory epilepsy; epilepsy pregnancy ... See more keywords