Lacosamide treatment of childhood refractory focal epilepsy: the first reported side effect in paediatric patients
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DOI: 10.1007/s00381-017-3586-8
Abstract: PurposeLacosamide (LCM) is an effective antiepileptic drug (AED) approved for the treatment of focal epilepsy in both children and adults. The aim of this observational study was to review our centre’s experience with LCM and… read more here.
Keywords: treatment; focal epilepsy; refractory focal; paediatric patients ... See more keywords
Pharmacokinetic evaluation of vigabatrin dose for the treatment of refractory focal seizures in children using adult and pediatric data
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DOI: 10.1016/j.eplepsyres.2019.01.002
Abstract: Vigabatrin is indicated as adjunctive therapy for refractory focal seizures. For children, European recommendations indicate maintenance doses varying from 30 to 100 mg/kg/day for this indication. Since cumulated dose was associated with retinal toxicity, it is… read more here.
Keywords: adult; seizures children; focal seizures; refractory focal ... See more keywords
Adjunctive cenobamate in highly active and ultra‐refractory focal epilepsy: A “real‐world” retrospective study
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DOI: 10.1111/epi.17549
Abstract: Recent clinical trials have shown that cenobamate substantially improves seizure control in focal‐onset drug‐resistant epilepsy (DRE). However, little is known about cenobamate's performance in highly active (≥20 seizures/month) and ultra‐refractory focal epilepsy (≥6 failed epilepsy… read more here.
Keywords: ultra refractory; highly active; refractory focal; focal epilepsy ... See more keywords