Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
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DOI: 10.1016/j.lfs.2020.118796
Abstract: AIMS In tumor cells, shikonin treatment has been reported to inhibit glycolysis by suppressing the activity of pyruvate kinase M2 (PKM2) and to induce apoptosis by increasing reactive oxygen species (ROS) production. However, hepatocellular carcinoma… read more here.
Keywords: hcc; glycolysis; apoptosis; metabolism ... See more keywords