Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study
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DOI: 10.1158/1078-0432.ccr-18-3127
Abstract: Purpose: CDKN2A loss is frequent in gastrointestinal stromal tumors (GISTs) and associated with aggressive outcome. Palbociclib is a CDK4 inhibitor with preclinical antitumor efficacy in tumors with P16/CDKN2A loss. Patients and Methods: This is a… read more here.
Keywords: stromal tumors; patients advanced; imatinib sunitinib; palbociclib patients ... See more keywords