Application of new targeted drugs in relapsed/refractory primary central nervous system lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2021.2019363
Abstract: ABSTRACT The prognosis of patients with relapsed and refractory primary central nervous system diffuse large B cell lymphoma (PCNSL) is poor and there is no standard salvage treatment currently available. Gene expression profiling and next-generation… read more here.
Keywords: targeted drugs; primary central; relapsed refractory; central nervous ... See more keywords
Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma: Final Analysis of KEYNOTE-170.
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DOI: 10.1182/blood.2022019340
Abstract: Previous analyses of the phase 2 KEYNOTE-170 (NCT02576990) study demonstrated effective antitumor activity and acceptable safety of pembrolizumab 200 mg given every 3 weeks for up to 35 cycles (~2 years) in patients with relapsed/refractory… read more here.
Keywords: cell; relapsed refractory; primary mediastinal; response ... See more keywords
A phase I/II study of thiotepa-based immunochemotherapy in relapsed/refractory primary CNS lymphoma: the TIER trial.
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DOI: 10.1182/bloodadvances.2021004779
Abstract: Relapsed or refractory primary central nervous system lymphoma (rrPCNSL) confers a poor prognosis with no accepted standard of care. Very few prospective studies have been conducted in this patient group. This multicenter, phase I/II study… read more here.
Keywords: relapsed refractory; phase; refractory primary; phase study ... See more keywords
Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma
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DOI: 10.1200/jco.19.01389
Abstract: PURPOSE Patients with relapsed or refractory primary mediastinal large B-cell lymphoma (rrPMBCL) have a poor prognosis, and their treatment represents an urgent and unmet need. Because PMBCL is associated with genetic aberrations at 9p24 and… read more here.
Keywords: response; keynote 170; refractory primary; cell ... See more keywords
Pemetrexed Plus Lenalidomide for Relapsed/Refractory Primary Central Nervous System Lymphoma: A Prospective Single-Arm Phase II Study
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DOI: 10.3389/fonc.2022.938421
Abstract: The prognosis of relapsed/refractory (R/R) primary central nervous system lymphoma (PCNSL) is dismal, and there are limited treatment options for these patients. This was a prospective single-arm phase II study of combined pemetrexed and lenalidomide… read more here.
Keywords: primary central; relapsed refractory; central nervous; system lymphoma ... See more keywords