Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer
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DOI: 10.1007/s10637-018-0688-4
Abstract: SummaryPurpose To determine the maximum tolerated dose (MTD) of F14512, a topoisomerase II inhibitor designed to target cancer cells through the polyamine transport system, (three-hour daily infusion given for 3 consecutive days every 3 weeks) in… read more here.
Keywords: topoisomerase inhibitor; resistant ovarian; study; platinum refractory ... See more keywords
1104. Risk Factors and Outcomes of Refractory and/or Resistant Cytomegalovirus (CMV) Infection after Allogeneic Hematopoietic Stem Cell Transplantation
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DOI: 10.1093/ofid/ofaa439.1290
Abstract: The epidemiology of CMV end-organ disease (EOD) after Hematopoietic Cell Transplant (HCT) in the era of preemptive therapy (PET) is defined. In contrast, less data exists on refractory and/or resistant (R/R) CMV. We report on… read more here.
Keywords: cmv; risk factors; refractory resistant; hct ... See more keywords
Effects of Pegylated Liposomal Doxorubicin and CA125 Level Variability Analysis in Platinum-refractory/resistant Recurrent Ovarian Cancer
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DOI: 10.21873/anticanres.15786
Abstract: Background/Aim: Ovarian cancer is a disease with significant impact, because more than half of cases exhibit recurrence despite platinum therapy. The choice of drug for cases of recurrence remains controversial, but the current option is… read more here.
Keywords: refractory resistant; platinum; ovarian cancer; pegylated liposomal ... See more keywords
Refractory and Resistant obesity: Dynamic Concepts, Contemporary Definitions.
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DOI: 10.47391/jpma.05-23
Abstract: Obesity is a chronic disease requiring a multi-disciplinary approach for its management. Despite multiple evolving and potent therapeutic options like GLP-1RA's and bariatric surgery, some patients do not achieve significant weight loss or expected metabolic… read more here.
Keywords: refractory resistant; concepts contemporary; resistant obesity; dynamic concepts ... See more keywords