A relative energy gradient (REG) study of the planar and perpendicular torsional energy barriers in biphenyl
Sign Up to like & getrecommendations! Published in 2018 at "Theoretical Chemistry Accounts"
DOI: 10.1007/s00214-018-2383-0
Abstract: Biphenyl is a prototype molecule, the study of which is important for a proper understanding of stereo-electronic effects. In the gas phase it has an equilibrium central torsion angle of ~ 45° and shows both a… read more here.
Keywords: energy; torsional energy; study; perpendicular torsional ... See more keywords
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17667-7
Abstract: A major challenge in chemotherapy is chemotherapy resistance in cells lacking p53. Here we demonstrate that NIP30, an inhibitor of the oncogenic REGγ-proteasome, attenuates cancer cell growth and sensitizes p53-compromised cells to chemotherapeutic agents. NIP30… read more here.
Keywords: chemotherapy; reg proteasome; inhibitor; p53 ... See more keywords
Expression of REGγ in atherosclerotic plaques and promotes endothelial cells apoptosis via the cyclophilin A pathway indicates functional implications in atherogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1639304
Abstract: ABSTRACT REGγ is a member of the 11S regulatory particles family of proteasome activators and has been shown to promote the degradation of intact cellular proteins in a ubiquitin- and ATP-independent manner in the progression… read more here.
Keywords: expression reg; reg atherosclerotic; expression; endothelial cells ... See more keywords
Trading Prior to the Disclosure of Material Information: Evidence from Regulation Fair Disclosure Form 8‐Ks *
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary Accounting Research"
DOI: 10.1111/1911-3846.12610
Abstract: Regulation Fair Disclosure (Reg FD) prohibits managers from releasing material information in non-public forums. Prior research concludes that Reg FD was effective at curtailing selective disclosure. However, these results have been called into question due… read more here.
Keywords: information; trading; disclosure; hour ... See more keywords
AB0741 T-reg and th17 levels in patients with systemic scleroderma
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.5270
Abstract: Background Regulatory T-cells (T-reg) may play an inhibitory role in the development of autoimmune diseases (AID) by suppressing the immune response to autoantigens. Impaired or decreased T-reg and/or increased Th17 cells may be responsible for… read more here.
Keywords: cd4 cd25; cell; reg; reg cell ... See more keywords
P181 An audit of paediatric staff attendance at premature deliveries ≤ 32 weeks gestation in cavan general hospital a local unit
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-epa.536
Abstract: Background and aims Based on the model of care for neonatal services in Ireland 2015, Cavan General Hospital is classified as a level 1 local unit. Therefore it offers routine and special care to infants… read more here.
Keywords: gestation; weeks gestation; scbu nurse; premature deliveries ... See more keywords
REGγ Contributes to Regulation of Hemoglobin and Hemoglobin δ Subunit
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DOI: 10.1155/2017/7295319
Abstract: Hemoglobin (Hb) is a family of proteins in red blood cells responsible for oxygen transport and vulnerable for oxidative damage. Hemoglobin δ subunit (HBD), a member of Hb family, is normally expressed by cells of… read more here.
Keywords: hemoglobin; hbd; via reg; hemoglobin subunit ... See more keywords
REGγ Controls Hippo Signaling and Reciprocal NF-κB–YAP Regulation to Promote Colon Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-2986
Abstract: Purpose: Colorectal cancer is one of the most commonly diagnosed cancers closely associated with inflammation and hyperactive growth. We previously demonstrated a regulatory circuit between the proteasome activator REGγ and NF-kappaB (NF-κB) during colon inflammation,… read more here.
Keywords: colorectal cancer; colon cancer; yap; cancer ... See more keywords
Abstract CT009: Results of a dose- and regimen-finding Phase Ib study of HDM201 in combination with ribociclib in patients with locally advanced or metastatic liposarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-ct009
Abstract: Background: Well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) is characterized by a consistent coamplification of human double minute 2 homolog (HDM2) and cyclin-dependent kinase 4 (CDK4) which inactivates the tumor suppressor pathways p53 and Rb, respectively. HDM201 is a… read more here.
Keywords: advanced metastatic; reg reg; locally advanced; hdm201 ribociclib ... See more keywords
11S Proteasome Activator REGγ Promotes Aortic Dissection by Inhibiting RBM3 (RNA Binding Motif Protein 3) Pathway
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DOI: 10.1161/hypertensionaha.122.19618
Abstract: Background: Aortic dissection (AD) is a life-threatening cardiovascular disorder with high mortality and lacking underlying mechanisms or effective treatments. REGγ, the 11S proteasome activator known to promote the degradation of cellular proteins in a ubiquitin-… read more here.
Keywords: rna binding; aortic dissection; contractile; vsmcs ... See more keywords
Survival by pattern of tumor progression during prior sorafenib (SOR) treatment in patients with hepatocellular carcinoma (HCC) in the phase III RESORCE trial comparing second-line treatment with regorafenib (REG) or placebo.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.229
Abstract: 229Background: HCC progression may be due to tumor growth or new intrahepatic or extrahepatic lesions. RECIST does not discriminate between progression patterns even though the prognosis may differ (Reig, Hepatology 2013). REG improves overall survival… read more here.
Keywords: treatment; progression; reg; sor ... See more keywords