The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells
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DOI: 10.1038/s41467-020-17667-7
Abstract: A major challenge in chemotherapy is chemotherapy resistance in cells lacking p53. Here we demonstrate that NIP30, an inhibitor of the oncogenic REGγ-proteasome, attenuates cancer cell growth and sensitizes p53-compromised cells to chemotherapeutic agents. NIP30… read more here.
Keywords: chemotherapy; reg proteasome; inhibitor; p53 ... See more keywords