A mutant KRAS‐induced factor REG4 promotes cancer stem cell properties via Wnt/β‐catenin signaling
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DOI: 10.1002/ijc.32728
Abstract: Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion… read more here.
Keywords: cancer stem; mutant kras; reg4; stem cell ... See more keywords
Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma
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DOI: 10.1177/1010428318761494
Abstract: Expression of regenerating islet-derived protein 4 (REG4), a secretory protein involved in cell differentiation and proliferation, is upregulated in inflammatory bowel diseases and in many gastrointestinal malignancies. The prognostic significance of its expression in pancreatic… read more here.
Keywords: reg4; tissue; expression; pancreatic ductal ... See more keywords
REG4 promotes the proliferation and anti-apoptosis of cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1012193
Abstract: Regenerating islet-derived 4 (REG4) gene was discovered by high-throughput sequencing of ulcerative colitis cDNA libraries. REG4 is involved in infection and inflammation by enhancing macrophage polarization to M2, via activation of epidermal growth factor receptor… read more here.
Keywords: proliferation anti; reg4; factor; anti apoptosis ... See more keywords