An Appearance Data‐Driven Model Visualizes Cell State and Predicts Mesenchymal Stem Cell Regenerative Capacity
Sign Up to like & getrecommendations! Published in 2022 at "Small Methods"
DOI: 10.1002/smtd.202200087
Abstract: Mesenchymal stem cells (MSCs) are widely used in treating various diseases. However, lack of a reliable evaluation approach to characterize the potency of MSCs has dampened their clinical applications. Here, a function‐oriented mathematical model is… read more here.
Keywords: appearance data; appearance; regenerative capacity; mesenchymal stem ... See more keywords
Cardiac regenerative capacity: an evolutionary afterthought?
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03831-9
Abstract: Cardiac regeneration is the outcome of the highly regulated interplay of multiple processes, including the inflammatory response, cardiomyocyte dedifferentiation and proliferation, neovascularization and extracellular matrix turnover. Species-specific traits affect these injury-induced processes, resulting in a… read more here.
Keywords: heart; regeneration; cardiac regenerative; regenerative capacity ... See more keywords
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.11.019
Abstract: Regenerative capacity is frequently impaired in aged organs. Stress to aged organs often causes scar formation (fibrosis) at the expense of regeneration. It remains to be defined how hematopoietic and vascular cells contribute to aging-induced… read more here.
Keywords: fibrosis; regeneration; vascular niche; hematopoietic vascular ... See more keywords
Cellular and Molecular Mechanism of Spinal Cord Regeneration in the Frog Xenopus laevis
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.090
Abstract: Little is known about the genetic mechanisms underlying high regenerative capacity of fishes, amphibians, reptiles in comparison with birds and mammals. According to the current opinion, the difference in their regenerative capacity rate is a… read more here.
Keywords: xenopus laevis; regeneration; molecular mechanism; regenerative capacity ... See more keywords
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor
Sign Up to like & getrecommendations! Published in 2022 at "Cell Discovery"
DOI: 10.1038/s41421-021-00361-3
Abstract: Regenerative capacity declines throughout evolution and with age. In this study, we asked whether metabolic programs underlying regenerative capability might be conserved across species, and if so, whether such metabolic drivers might be harnessed to… read more here.
Keywords: regenerative capacity; cross species; metabolomic analysis; stem cells ... See more keywords
Vascular Regenerative Capacity and the Obesity Paradox in Coronary Artery Disease
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.120.315703
Abstract: Supplemental Digital Content is available in the text. Objective: The underlying pathobiology of the paradoxical relationship between obesity and adverse outcomes in coronary artery disease (CAD) is unclear. Our objective was to determine the association… read more here.
Keywords: obesity; obesity paradox; regenerative capacity; cpc counts ... See more keywords
Associations Between Inflammation, Cardiovascular Regenerative Capacity, and Cardiovascular Events: A Cohort Study
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.316574
Abstract: Supplemental Digital Content is available in the text. Objective: Circulating progenitor cells possess immune modulatory properties and might mitigate inflammation that is characteristic of patients with coronary artery disease. We hypothesized that patients with fewer… read more here.
Keywords: regenerative capacity; coronary artery; study; cohort ... See more keywords
Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity
Sign Up to like & getrecommendations! Published in 2018 at "Current Cardiology Reviews"
DOI: 10.2174/1573403x14666180726112303
Abstract: Background: The endothelium plays an important role in cardiovascular regulation, from blood flow to platelet aggregation, immune cell infiltration and demargination. A dysfunctional endo-thelium leads to the onset and progression of Cardiovascular Disease (CVD). The… read more here.
Keywords: diet exercise; exercise obesity; regenerative capacity; function ... See more keywords
Molecular Dissection of the Regenerative Capacity of Forest Tree Species: Special Focus on Conifers
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2018.01943
Abstract: Somatic embryogenesis (SE) and organogenesis have become leading biotechnologies for forest tree improvement and the implementation of multi-varietal forestry. Despite major advances in clonal propagation using these technologies, many forest tree species, such as conifers,… read more here.
Keywords: dissection regenerative; molecular dissection; regenerative capacity; tree species ... See more keywords
Regenerative capacity of Müller cells and their modulation as a tool to treat retinal degenerations
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.340408
Abstract: mediated by TGFβ1 and TGFβ2 - during gliosis in mice. We also detected increased leucine zipper transcription factors (Tsc22), such as Tsc22d1, in Müller cells. In agreement with our findings, Tsc22 has been shown to… read more here.
Keywords: cells modulation; ller; modulation tool; regenerative capacity ... See more keywords