Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01883
Abstract: By replacing a phenolic ring of (E)-resveratrol with an 1,3,4-oxadiazol-2(3H)-one heterocycle, new resveratrol-based multitarget-directed ligands (MTDLs) were obtained. They were evaluated in several assays related to oxidative stress and inflammation (monoamine oxidases, nuclear erythroid 2-related… read more here.
Keywords: regenerative pathways; defensive regenerative; resveratrol based; stimulate defensive ... See more keywords
A Common Link in Neurovascular Regenerative Pathways: Protein Kinase B (Akt).
Sign Up to like & getrecommendations! Published in 2022 at "Current neurovascular research"
DOI: 10.2174/1567202619666220209111655
Abstract: read more here.
Keywords: link neurovascular; pathways protein; neurovascular regenerative; protein kinase ... See more keywords