Catalyst-free regio- and chemoselective addition of secondary phosphine oxides to isoquinolines
Sign Up to like & getrecommendations! Published in 2020 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-020-2874-8
Abstract: Isoquinolines react with secondary phosphine oxides without catalyst (70–75 °C, 10–15 h, without solvent or in MeCN) to chemo- and regioselectively form previously unknown diadducts, 1,3-bis(diorganylphosphoryl)-1,2,3,4-tetrahydroisoquinolines, in high yields (85–95%). read more here.
Keywords: free regio; secondary phosphine; phosphine oxides; regio chemoselective ... See more keywords
Regio- and Chemoselective Copper-Catalyzed Formal [2+2+2] Cycloaddition of Primary Amines with Arylacetylenes to 2,4,5-Trisubstituted Pyridines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02606
Abstract: Disclosed herein is an efficient strategy for the synthesis of 2,4,5-trisubstituted pyridines via CuI/NBS-catalyzed formal intermolecular [2+2+2] cycloaddition of easily available primary amines and nonactivated terminal alkynes. Moreover, this given reaction features a new mode… read more here.
Keywords: catalyzed formal; regio chemoselective; chemoselective copper; trisubstituted pyridines ... See more keywords
Iron(III)-Catalyzed Domino Claisen Rearrangement/Regio- and Chemoselective Aerobic Dehydrogenative Cyclization of β-Naphthyl-Substituted-Allenylmethyl Ether.
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DOI: 10.1021/acs.orglett.8b03941
Abstract: An FeCl3-catalyzed allenic Claisen rearrangement/regio- and chemoselective aerobic dehydrogenative cyclization domino reaction is developed, providing a wide range of 2-aryl/alkyl, 3-(substituted-vinyl)naphtho[2,1- b]furans in high yields at 95-130 °C in an atom- and step-economic fashion. Mechanistic… read more here.
Keywords: rearrangement regio; claisen rearrangement; regio; aerobic dehydrogenative ... See more keywords
Regio- and chemoselective synthesis of nitrogen-containing heterocycles via the oxidative cascade cyclization of unactivated 1,n-enynes.
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DOI: 10.1039/c9cc07820g
Abstract: The development of a method for performing radical initiated intramolecular cascade cyclization of 1,n-enynes provided a competent protocol for producing structurally diverse complex heterocycles. Herein, we demonstrate I2/TBHP promoted, solvent controlled, regio- and chemoselective 5-exo-trig… read more here.
Keywords: cascade cyclization; cyclization; nitrogen containing; regio chemoselective ... See more keywords
Regio- and chemoselective hydroamination of unactivated alkenes with anthranils via NiH-catalysis.
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DOI: 10.1039/d2cc07052a
Abstract: A NiH-catalyzed polarity-reversed hydroamination of β,γ-, γ,δ- and δ,ε-unsaturated alkenes with electrophilic anthranils was developed. This reaction proceeds in a highly regio- and chemoselective manner to afford γ, δ and ε-arylamines bearing a carbonyl or… read more here.
Keywords: hydroamination unactivated; regio chemoselective; hydroamination; chemoselective hydroamination ... See more keywords