Cobalt-Catalyzed Regio-, Diastereo-, and Enantioselective Reductive Coupling of Internal Alkynes with Cyclobutenes.
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DOI: 10.1021/acs.orglett.5c01695
Abstract: Herein, we report the cobalt-catalyzed asymmetric ene-yne reductive coupling of internal alkynes and unactivated cyclobutenes. The reaction produced densely functionalized chiral vinyl cyclobutanes in up to 92% yields with excellent absolute and relative stereocontrol (>99%… read more here.
Keywords: catalyzed regio; coupling internal; reductive coupling; cobalt catalyzed ... See more keywords
Asymmetric Dearomative [2 + 2] Photocycloaddition of Quinoline and Indole Derivatives with Bicyclo[1.1.0]butanes.
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DOI: 10.1021/jacs.5c12057
Abstract: The dearomative photocycloaddition reactions of (hetero)arene feedstocks have emerged as an efficient platform for the construction of three-dimensional complexity, which is of increasing interest in medicinal chemistry. Nevertheless, the catalytic asymmetric version of such transformations… read more here.
Keywords: dearomative photocycloaddition; asymmetric dearomative; bicyclo butanes; regio diastereo ... See more keywords