REGIO- AND DIASTEREOSELECTIVE SYNTHESIS OF N -SUBSTITUTED 2-ACYL-3-ARYL-3,5-DIHYDROFURO[3,2- c ]PYRIDIN-4(2 H )-ONES
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DOI: 10.1007/5898
Abstract: Трехкомпонентной конденсацией генерируемых in situ ацилметилидов пиридиния с ароматическими альдегидами и 4-гидрокси-6-метилпиридонами получена серия 3-арил-2-ацил-3,5-дигидрофуро[3,2- c ]пиридин-4(2 H )-онов. Реакция протекает диастереоселективно с образованием транс -изомеров и представляет собой каскадный процесс, включающий конденсацию Кнёвенагеля, карбо-реакцию… read more here.
Keywords: diastereoselective synthesis; synthesis substituted; regio diastereoselective; acyl aryl ... See more keywords
Regio- and diastereoselective synthesis of N-substituted 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones
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DOI: 10.1007/s10593-020-02832-z
Abstract: The three-component condensation of pyridinium acylmethylides generated in situ with aromatic aldehydes and 4-hydroxy-6-methylpyridones gave a series of 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones. The reaction proceeds diastereoselectively with the formation of trans-isomers and represents a cascade process involving the… read more here.
Keywords: dihydrofuro pyridin; regio diastereoselective; pyridin ones; acyl aryl ... See more keywords
Regio- and Diastereoselective Carbometalation Reaction of Cyclopropenes
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DOI: 10.1021/acs.accounts.2c00424
Abstract: Conspectus The various facets of the chemistry of cyclopropane derivatives, the smallest carbocycle, are amazingly diverse and continue to fascinate theoreticians, synthetic or structural chemists having interest in fundamental physical, medicinal chemistry, and natural product… read more here.
Keywords: regio diastereoselective; reaction; chemistry; synthesis ... See more keywords
Regio- and Diastereoselective Access to Fused Isoxazolidines via Ru(II)-Catalyzed C-H Activation of Nitrones and Coupling with Perfluoroalkylolefins.
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DOI: 10.1021/acs.orglett.7b03775
Abstract: The synthsis of fluorinated isoxazolidines in bicyclic settings has been realized via Ru(II)-catalyzed C-H activation of aryl nitrones with perfluoroalkyl-substituted olefins as the coupling partner. The reaction proceeded via initial chelation-assisted C(aryl)-H allylation followed by… read more here.
Keywords: diastereoselective access; via catalyzed; regio diastereoselective; catalyzed activation ... See more keywords
Copper-Catalyzed Regio- and Diastereoselective Additions of Boron-Stabilized Carbanions to Heteroarenium Salts: Synthesis of Azaheterocycles Containing Contiguous Stereocenters
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DOI: 10.1021/acscatal.0c04474
Abstract: Nucleophilic addition of diborylalkyl reagents to N-alkyl or N-acylpyridinium and related heteroarenium salts has been developed as a key step for the synthesis of nonaromatic nitrogen heterocycles... read more here.
Keywords: heteroarenium; catalyzed regio; regio diastereoselective; heteroarenium salts ... See more keywords
Regio- and Diastereoselective 1,3-Dipolar Cycloadditions of 1,2,4-Triazin-1-ium Ylides: a Straightforward Synthetic Route to Polysubstituted Pyrrolo[2,1-f][1,2,4]triazines
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DOI: 10.1021/acsomega.2c02276
Abstract: A synthetic strategy to pyrrolo[2,1-f][1,2,4]triazines is reported. We show that various synthetically easily accessible 1,2,4-triazines can be efficiently alkylated under mild conditions to provide the corresponding 1-alkyl-1,2,4-triazinium salts. These bench-stable salts serve as precursors to… read more here.
Keywords: regio diastereoselective; triazin ium; diastereoselective dipolar; cycloadditions triazin ... See more keywords
Additive-free regio- and diastereoselective construction of fully-substituted isoxazolidines employing diazo compounds
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DOI: 10.1039/c8qo01421c
Abstract: An efficient additive-free three-component access to densely functionalized isoxazolidines using diazo compounds, nitrosoarene, and allenic esters has been uncovered. read more here.
Keywords: additive free; free regio; diazo compounds; construction fully ... See more keywords
Regio- and diastereoselective synthesis of unsymmetrical 1,4-diketone-derived (Z)-monosilyl enol ethers via siloxyallylpotassium intermediates.
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DOI: 10.1039/d2cc07097a
Abstract: This paper describes the regio- and diastereoselective synthesis of unsymmetrical 1,4-diketone-derived (Z)-monosilyl enol ethers from 1-arylallyloxysilanes and Weinreb amides using (trimethylsilyl)methylpotassium as a base. The metalation of 1-arylallyloxysilanes to generate siloxyallylpotassiums is the key step… read more here.
Keywords: diastereoselective synthesis; unsymmetrical diketone; regio diastereoselective; diketone derived ... See more keywords