Ligand-Dependent Regiodivergent Enantioselective Allylic Alkylations of α-Trifluoromethylated Ketones.
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DOI: 10.1021/acs.orglett.1c00329
Abstract: The asymmetric introduction of the CF3 unit is a powerful tool for modifying pharmacokinetic properties and slowing metabolic degradation in medicinal chemistry. A catalytic and enantioselective addition of α-CF3 enolates allows for expeditious access to… read more here.
Keywords: alkylations trifluoromethylated; regiodivergent enantioselective; dependent regiodivergent; enantioselective allylic ... See more keywords