Non-catalytic-Region Mutations Conferring Transition of Class A β-Lactamases Into ESBLs
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DOI: 10.3389/fmolb.2020.598998
Abstract: Despite class A ESBLs carrying substitutions outside catalytic regions, such as Cys69Tyr or Asn136Asp, have emerged as new clinical threats, the molecular mechanisms underlying their acquired antibiotics-hydrolytic activity remains unclear. We discovered that this non-catalytic-region… read more here.
Keywords: esbls; region mutations; non catalytic; class ... See more keywords