Chromatin accessibility of primary human cancers ties regional mutational processes and signatures with tissues of origin
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DOI: 10.1371/journal.pcbi.1010393
Abstract: Somatic mutations in cancer genomes are associated with DNA replication timing (RT) and chromatin accessibility (CA), however these observations are based on normal tissues and cell lines while primary cancer epigenomes remain uncharacterised. Here we… read more here.
Keywords: cancer; mutational processes; normal tissues; regional mutational ... See more keywords