Regioselective C-H Active Carbonylation via 1,4-Palladium Migration.
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DOI: 10.1021/acs.orglett.3c00567
Abstract: We report a highly regioselective three-component coupling reaction of styrene, CO gas, and an amine compound to synthesize multisubstituted α,β-unsaturated amides, which involves a palladium-catalyzed sequential 1,4-palladium migration, C(sp2)-H activation, carbonylation, and amination. Salient features… read more here.
Keywords: regioselective active; palladium migration; palladium; active carbonylation ... See more keywords