Substrate controlled, regioselective carbopalladation for the one-pot synthesis of C4-substituted tetrahydroisoquinoline analogues
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DOI: 10.1039/d0ra01539c
Abstract: 6-Exo-trig cyclization reaction through regioselective carbopalladation was demonstrated with N-(2-halobenzyl)-N-allylamines to furnish the corresponding C4-substituted tetrahydroisoquinoline derivatives. The scope of the reaction was extended to the synthesis of C4-quaternary tetrahydroisoquinoline derivatives also. The nature of… read more here.
Keywords: substrate controlled; regioselective carbopalladation; carbopalladation; substituted tetrahydroisoquinoline ... See more keywords