Photocatalytic Regioselective [2 + 2 + 1] Radical Annulation of Alkenes with tert-Butyl Nitrite and gem-Dihalides.
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DOI: 10.1021/acs.orglett.2c03635
Abstract: A visible-light photocatalytic regioselective [2 + 2 + 1] radical annulation reaction of alkenes, tert-butyl nitrite, and gem-dihalides has been developed. The protocol provides an efficient and practical approach to obtain isoxazolines in good yields… read more here.
Keywords: gem dihalides; butyl nitrite; radical annulation; photocatalytic regioselective ... See more keywords
Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes.
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DOI: 10.1021/jacs.3c03607
Abstract: Substituted arenes are ubiquitous in molecules with medicinal functions, making their synthesis a critical consideration when designing synthetic routes. Regioselective C-H functionalization reactions are attractive for preparing alkylated arenes; however, the selectivity of existing methods… read more here.
Keywords: alkylation arenes; arenes using; alkylation; radical alkylation ... See more keywords
Photoinduced remote regioselective radical alkynylation of unactivated C-H bonds.
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DOI: 10.1039/d1cc06885g
Abstract: A method for the remote regioselective alkynylation of unactivated C(sp3)-H bonds in diverse aliphatic amides by photogenerated amidyl radicals has been developed. The site-selectivity is dominated via a 1,5-hydrogen atom transfer (HAT) process of the… read more here.
Keywords: photoinduced remote; radical alkynylation; regioselective radical; remote regioselective ... See more keywords