Mn(I)‐NNSe Pincer Complex Catalyzed Regioselective Synthesis of Bisindolylmethanes under Base and Solvent‐Free Conditions
Sign Up to like & getrecommendations! Published in 2025 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202500323
Abstract: Here, we present a catalytic, regioselective synthesis of bisindolylmethanes through the reaction of indoles and benzyl alcohol derivatives mediated by metal‐ligand cooperative catalysis. The reaction is catalyzed by an earth‐abundant manganese‐NNSe pincer complex without the… read more here.
Keywords: synthesis bisindolylmethanes; nnse pincer; regioselective synthesis; pincer complex ... See more keywords
Transition Metal‐Free One‐Pot Approach: Regioselective Synthesis of Pyrrolo[3,4‐b]quinolin‐1‐one Derivatives from o‐Alkynylquinoline‐3‐carbonitriles
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400582
Abstract: A KOtBu‐promoted robust strategy has been described for the regioselective synthesis of pyrrolo[3,4‐b]quinolin‐1‐one and naphthyridin‐1(2H)‐one derivatives from o‐alkynylquinolinecarbonitriles in good to excellent yields. The reaction proceeds through in‐situ transformation of nitrile moiety into amide group… read more here.
Keywords: synthesis pyrrolo; one pot; pyrrolo quinolin; one derivatives ... See more keywords
Regioselective Synthesis of Mono‐ and Dispiropyrazoline Derivatives via 1,3‐dipolar Cycloaddition with Nitrilimines
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DOI: 10.1002/jhet.2684
Abstract: The 1,3-dipolar cycloaddition reaction of (E,E)-1,3-bis(arylidene)indan-2-one with diarylnitrilimines, generated in situ via dehydrohalogenation of the corresponding hydrazonoyl chlorides , affords predominantly monospiropyrazolines and as a mixture of diastereoisomers. Also dispiropyrazolines are formed in moderate yields.… read more here.
Keywords: cycloaddition; mono dispiropyrazoline; synthesis mono; dispiropyrazoline derivatives ... See more keywords
Eco‐friendly Regioselective Synthesis, Biological Evaluation of Some New 5‐acylfunctionalized 2‐(1H‐pyrazol‐1‐yl)thiazoles as Potential Antimicrobial and Anthelmintic Agents
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DOI: 10.1002/open.202400142
Abstract: Abstract The present study describes an eco‐friendly NBS‐assisted regioselective synthesis of new 5‐acylfunctionalized 5‐acylfunctionalized 2‐(1H‐pyrazol‐1‐yl)thiazoles by condensation of 3,5‐dimethyl‐1H‐pyrazole‐1‐carbothioamide with unsymmetrical 1,3‐diketones under solvent‐free conditions. The structural elucidation of the newly synthesized compounds was accomplished… read more here.
Keywords: eco friendly; acylfunctionalized pyrazol; pyrazol thiazoles; new acylfunctionalized ... See more keywords
REGIOSELECTIVE SYNTHESIS OF 1,3,5-TRISUBSTITUTED PYRAZOLES CONTAINING AN ANTHRANILIC ACID MOTIF
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DOI: 10.1007/5109
Abstract: An effective method was developed for the synthesis of 1,3,5-trisubstituted pyrazoles by using acetylenic ketones, obtained from ethyl 5-ethynylanthranilate, in reactions with substituted hydrazines and hydrazides. It was shown that the cyclization of ethyl 5-(3-aryl-3-oxopropinyl)anthranilates… read more here.
Keywords: containing anthranilic; pyrazoles containing; trisubstituted pyrazoles; synthesis trisubstituted ... See more keywords
Two-step regioselective synthesis of 1,2-difluorobenzenes from chlorotrifluoroethylene and buta-l,3-dienes
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DOI: 10.1007/s11172-020-2724-8
Abstract: The gas-phase copyrolysis of chlorotrifluoroethylene with buta-1,3-diene, penta-1,3-diene, or isoprene in a flow reactor at 440–480°C gave 4-chloro-4,5,5-trifluorocyclohex-1-enes. The latter treated with aqueous KOH under condition of phase-transfer catalysis were selectively converted into 1,2-difluorobenzene, 2,3-difluorotoluene,… read more here.
Keywords: chlorotrifluoroethylene buta; step regioselective; synthesis difluorobenzenes; difluorobenzenes chlorotrifluoroethylene ... See more keywords
Regioselective synthesis of 5-aryl azo salicylaldehydes catalyzed by Zn/SBA-15
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DOI: 10.1007/s11696-019-00790-1
Abstract: Synthesis of (E)-2-hydroxy-5-(aryldiazenyl)benzaldehydes was investigated. Various Lewis acids were tested as catalyst to achieve regioselectivity. In addition to various commercial catalysts, mesoporous Zn/SBA-15 was synthesized through a modified direct method with chloride salt as zinc… read more here.
Keywords: aryl azo; synthesis; azo salicylaldehydes; regioselective synthesis ... See more keywords
Reaction of CF3-ynones with methyl thioglycolate. Regioselective synthesis of 3-CF3-thiophene derivatives
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DOI: 10.1016/j.jfluchem.2018.07.013
Abstract: Abstract Efficient regioselective synthesis of 3-CF3-substituted thiophene derivatives was elaborated using addition of methyl thioglycolate to CF3-ynones in the presence of sodium methoxide. read more here.
Keywords: cf3 ynones; cf3; synthesis cf3; thiophene derivatives ... See more keywords
Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans
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DOI: 10.1016/j.mencom.2018.11.020
Abstract: The effective and regioselective synthesis of new (2-hydrazinylthiazol-4-yl)furoxan hydrobromides based on the condensation of (bromoacetyl)furoxans with thiosemicarbazide has been developed. The cytotoxic activity of their derivatives (with hydrazone, 4-thiazolo[2.3-c][1,2,4]triazole or pyrrole moieties) against two human… read more here.
Keywords: cytotoxic; synthesis structural; structural diversification; regioselective synthesis ... See more keywords
Complementary regioselective synthesis of 3,5-disubstituted isoxazoles from ynones
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DOI: 10.1016/j.tet.2018.09.043
Abstract: Abstract Two regioselective synthetic routes towards 3,5-disubstituted isoxazoles from ynones are reported. One route takes place via first converting the ynones to ynone O-methyl oximes, followed by a palladium-catalyzed intramolecular cyclization. The other involves the… read more here.
Keywords: disubstituted isoxazoles; complementary regioselective; isoxazoles ynones; synthesis disubstituted ... See more keywords
Base-promoted regioselective synthesis of 1,2,3,4-terahydroquinolines and quinolines from N-boc-3-piperidone
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DOI: 10.1016/j.tet.2019.130695
Abstract: Abstract An efficient synthesis of 1,2,3,4-tetrahydroquinolines with donor and acceptor group has been delineated by base mediated ring transformation of 6-aryl-4-substituted-2H-pyran-2-one-3-carbonitriles by N-boc-3-piperidone followed by consecutive deprotection of Boc group under acidic conditions. This reaction… read more here.
Keywords: promoted regioselective; boc piperidone; base promoted; regioselective synthesis ... See more keywords