Regioselective Synthesis of Mono‐ and Dispiropyrazoline Derivatives via 1,3‐dipolar Cycloaddition with Nitrilimines
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DOI: 10.1002/jhet.2684
Abstract: The 1,3-dipolar cycloaddition reaction of (E,E)-1,3-bis(arylidene)indan-2-one with diarylnitrilimines, generated in situ via dehydrohalogenation of the corresponding hydrazonoyl chlorides , affords predominantly monospiropyrazolines and as a mixture of diastereoisomers. Also dispiropyrazolines are formed in moderate yields.… read more here.
Keywords: cycloaddition; mono dispiropyrazoline; synthesis mono; dispiropyrazoline derivatives ... See more keywords
REGIOSELECTIVE SYNTHESIS OF 1,3,5-TRISUBSTITUTED PYRAZOLES CONTAINING AN ANTHRANILIC ACID MOTIF
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DOI: 10.1007/5109
Abstract: An effective method was developed for the synthesis of 1,3,5-trisubstituted pyrazoles by using acetylenic ketones, obtained from ethyl 5-ethynylanthranilate, in reactions with substituted hydrazines and hydrazides. It was shown that the cyclization of ethyl 5-(3-aryl-3-oxopropinyl)anthranilates… read more here.
Keywords: containing anthranilic; pyrazoles containing; trisubstituted pyrazoles; synthesis trisubstituted ... See more keywords
Two-step regioselective synthesis of 1,2-difluorobenzenes from chlorotrifluoroethylene and buta-l,3-dienes
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DOI: 10.1007/s11172-020-2724-8
Abstract: The gas-phase copyrolysis of chlorotrifluoroethylene with buta-1,3-diene, penta-1,3-diene, or isoprene in a flow reactor at 440–480°C gave 4-chloro-4,5,5-trifluorocyclohex-1-enes. The latter treated with aqueous KOH under condition of phase-transfer catalysis were selectively converted into 1,2-difluorobenzene, 2,3-difluorotoluene,… read more here.
Keywords: chlorotrifluoroethylene buta; step regioselective; synthesis difluorobenzenes; difluorobenzenes chlorotrifluoroethylene ... See more keywords
Regioselective synthesis of 5-aryl azo salicylaldehydes catalyzed by Zn/SBA-15
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DOI: 10.1007/s11696-019-00790-1
Abstract: Synthesis of (E)-2-hydroxy-5-(aryldiazenyl)benzaldehydes was investigated. Various Lewis acids were tested as catalyst to achieve regioselectivity. In addition to various commercial catalysts, mesoporous Zn/SBA-15 was synthesized through a modified direct method with chloride salt as zinc… read more here.
Keywords: aryl azo; synthesis; azo salicylaldehydes; regioselective synthesis ... See more keywords
Reaction of CF3-ynones with methyl thioglycolate. Regioselective synthesis of 3-CF3-thiophene derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2018.07.013
Abstract: Abstract Efficient regioselective synthesis of 3-CF3-substituted thiophene derivatives was elaborated using addition of methyl thioglycolate to CF3-ynones in the presence of sodium methoxide. read more here.
Keywords: cf3 ynones; cf3; synthesis cf3; thiophene derivatives ... See more keywords
Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans
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DOI: 10.1016/j.mencom.2018.11.020
Abstract: The effective and regioselective synthesis of new (2-hydrazinylthiazol-4-yl)furoxan hydrobromides based on the condensation of (bromoacetyl)furoxans with thiosemicarbazide has been developed. The cytotoxic activity of their derivatives (with hydrazone, 4-thiazolo[2.3-c][1,2,4]triazole or pyrrole moieties) against two human… read more here.
Keywords: cytotoxic; synthesis structural; structural diversification; regioselective synthesis ... See more keywords
Complementary regioselective synthesis of 3,5-disubstituted isoxazoles from ynones
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DOI: 10.1016/j.tet.2018.09.043
Abstract: Abstract Two regioselective synthetic routes towards 3,5-disubstituted isoxazoles from ynones are reported. One route takes place via first converting the ynones to ynone O-methyl oximes, followed by a palladium-catalyzed intramolecular cyclization. The other involves the… read more here.
Keywords: disubstituted isoxazoles; complementary regioselective; isoxazoles ynones; synthesis disubstituted ... See more keywords
Base-promoted regioselective synthesis of 1,2,3,4-terahydroquinolines and quinolines from N-boc-3-piperidone
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DOI: 10.1016/j.tet.2019.130695
Abstract: Abstract An efficient synthesis of 1,2,3,4-tetrahydroquinolines with donor and acceptor group has been delineated by base mediated ring transformation of 6-aryl-4-substituted-2H-pyran-2-one-3-carbonitriles by N-boc-3-piperidone followed by consecutive deprotection of Boc group under acidic conditions. This reaction… read more here.
Keywords: promoted regioselective; boc piperidone; base promoted; regioselective synthesis ... See more keywords
Triflic acid catalysed regioselective synthesis of substituted naphthalenes by benzannulation of carbonyls with alkynes
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DOI: 10.1016/j.tet.2021.132214
Abstract: Abstract An interesting and facile triflic acid catalysed annulation of α-aryl carbonyls with arylalkynes is presented for the regioselective synthesis of substituted naphthalenes. The annulation reaction involves a sequence of electrophilic attack of carbonyl on… read more here.
Keywords: triflic acid; synthesis substituted; carbonyls; acid catalysed ... See more keywords
Regioselective Synthesis of 6-Chlorofulvene and 6-Aminofulvene via Keto–Enol Tautomerism
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DOI: 10.1021/acs.jchemed.0c00039
Abstract: Keto–enol tautomerism is a special example of structural isomerism. In this experiment, 6-chlorofulvene is predominantly yielded during the chlorination reaction of 6′-hydroxyfulvene with POCl3 in ... read more here.
Keywords: keto enol; regioselective synthesis; chlorofulvene; enol tautomerism ... See more keywords
Regioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds.
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DOI: 10.1021/acs.orglett.1c01398
Abstract: We describe, for the first time, a highly regioselective hydrosilylation of propargylic amines. The reaction utilizes a PtCl2/XantPhos catalyst system to deliver hydrosilanes across the alkyne to afford multifunctional allylic amines in high yields. The… read more here.
Keywords: multifunctional allylic; amines access; allylic amines; synthesis multifunctional ... See more keywords