Resound Trial: A phase 2 study of regorafenib in patients with thymoma (type B2-B3) and thymic carcinoma previously treated with chemotherapy.
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DOI: 10.1002/cncr.33990
Abstract: BACKGROUND Angiogenesis has an important role in thymic epithelial tumors (TETs). Regorafenib inhibits vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptor β (PDGFR-β), and fibroblast growth factor receptors (FGFRs). This study explored the… read more here.
Keywords: thymic carcinoma; study; rate; previously treated ... See more keywords
Pharmacokinetics of the oral multikinase inhibitor regorafenib and its association with real‐world treatment outcomes
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DOI: 10.1007/s10637-021-01115-4
Abstract: Purpose Despite the established activity of regorafenib in metastatic colorectal cancer (CRC), gastrointestinal stromal tumor (GIST), and hepatocellular carcinoma (HCC), its toxicity profile has limited clinical use. We aimed to evaluate the pharmacokinetics of regorafenib… read more here.
Keywords: real world; treatment; regorafenib; oral multikinase ... See more keywords
Regorafenib Is Associated With Increased Skeletal Muscle Loss Compared to TAS-102 in Metastatic Colorectal Cancer.
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DOI: 10.1016/j.clcc.2019.04.003
Abstract: BACKGROUND Current guidelines of the National Comprehensive Cancer Network and the European Society of Medical Oncology recommend regorafenib or trifluridine/tipiracil (TAS-102) for third-line therapy of metastatic colorectal cancer (mCRC). We evaluated the impact of regorafenib… read more here.
Keywords: muscle; tas 102; cancer; skeletal muscle ... See more keywords
Evolving role of regorafenib for the treatment of advanced cancers.
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DOI: 10.1016/j.ctrv.2020.101993
Abstract: Regorafenib is an oral tyrosine kinase inhibitor (TKI) approved for the treatment of refractory metastatic colorectal cancer (mCRC), advanced gastrointestinal stromal tumors (GIST) previously treated with imatinib and sunitinib, and unresectable hepatocellular carcinoma (HCC) following… read more here.
Keywords: placebo controlled; treatment; controlled phase; randomized placebo ... See more keywords
Receptor tyrosine kinase inhibition by regorafenib/sorafenib inhibits growth and invasion of meningioma cells.
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DOI: 10.1016/j.ejca.2016.12.004
Abstract: Systemic chemotherapeutic treatment for unresectable and/or aggressive meningiomas is still unsatisfying. PDGF receptor (PDGFR)-mediated activation of mitogenic signalling has been shown to be active in meningiomas. Therefore, we evaluate in vitro and in vivo the effects of… read more here.
Keywords: inhibition; sorafenib; sorafenib regorafenib; meningioma ... See more keywords
A double-blind placebo-controlled randomized phase II trial assessing the activity and safety of regorafenib in non-adipocytic patients previously treated with both chemotherapy and pazopanib.
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DOI: 10.1016/j.ejca.2019.12.001
Abstract: BACKGROUND Metastatic soft tissue sarcomas (STSs) management remains an unmet medical need. We assessed the activity and safety of regorafenib in patients with metastatic non-adipocytic STS who were previously treated with both chemotherapy and pazopanib.… read more here.
Keywords: non adipocytic; activity safety; versus; placebo ... See more keywords
Oncologic Outcomes in Metastatic Colorectal Cancer with Regorafenib with FOLFIRI as a Third- or Fourth-Line Setting123
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DOI: 10.1016/j.tranon.2018.12.003
Abstract: BACKGROUND: To evaluate the efficacy and toxicities of regorafenib plus irinotecan, dose-escalated on the basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping, in previously heavily treated metastatic colorectal cancer (mCRC) and the prognostic values of… read more here.
Keywords: metastatic colorectal; colorectal cancer; egfr expression; regorafenib folfiri ... See more keywords
PP94 Clinical Effectiveness Of Regorafenib For Metastatic Colorectal Cancer
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DOI: 10.1017/s0266462319002320
Abstract: Introduction Colorectal cancer (CRC) is the third most common malignant neoplasm among men and the second most common among women. According to the World Cancer Report, the number of people suffering from this disease is… read more here.
Keywords: metastatic crc; treatment; colorectal cancer; regorafenib ... See more keywords
Relapsed glioblastomas respond to regorafenib
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DOI: 10.1038/s41571-018-0161-5
Abstract: Data from a phase II trial involving patients with relapsed glioblastoma following chemoradiotherapy, a setting in which few evidence-based therapies are currently available, demonstrate the superiority of the anti-angiogenic tyrosine-kinase inhibitor regorafenib over lomustine chemotherapy.… read more here.
Keywords: glioblastomas respond; relapsed glioblastomas; oncology; regorafenib ... See more keywords
Regorafenib induces the apoptosis of gastrointestinal cancer-associated fibroblasts by inhibiting AKT phosphorylation.
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DOI: 10.1089/scd.2022.0088
Abstract: Cancer-associated fibroblasts (CAFs) are a key component of tumor microenvironment and are essential for tumorigenesis and development. Regorafenib is a multikinase inhibitor that targets CAFs and suppresses tumor growth. Here, we investigated the effects of… read more here.
Keywords: cafs; apoptosis; regorafenib; cancer associated ... See more keywords
Interaction Between Sex and Organic Anion‐Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib‐N‐Oxide and Regorafenib‐Glucuronide in Mice
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DOI: 10.1111/cts.12630
Abstract: Regorafenib, a multikinase inhibitor used in the treatment of various solid tumors, undergoes extensive uridine 5′‐diphosphate glucuronosyltransferase (Ugt)1a9‐mediated glucuronidation to form regorafenib‐N‐β‐glucuronide (M7; RG), but the contribution of hepatic uptake transporters, such as organic anion‐transporting… read more here.
Keywords: anion transporting; regorafenib glucuronide; sex; mice ... See more keywords