General Anesthetics Regulate Autophagy via Modulating the Inositol 1,4,5-Trisphosphate Receptor: Implications for Dual Effects of Cytoprotection and Cytotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11607-0
Abstract: General anesthetics are both neuroprotective and neurotoxic with unclear mechanisms. General anesthetics may control cell survival via their effects on autophagy by activation of type 1 inositol triphosphate receptor (InsP3R-1). DT40 or SH-SY5Y cells with… read more here.
Keywords: regulate autophagy; propofol; cytoprotection; anesthetics regulate ... See more keywords
The ATG4 protease integrates redox and stress signals to regulate autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of experimental botany"
DOI: 10.1093/jxb/erab063
Abstract: Autophagy is a highly conserved degradative pathway that ensures cellular homeostasis through the removal of damaged or useless intracellular components including proteins, membranes or even entire organelles. A main hallmark of autophagy is the biogenesis… read more here.
Keywords: regulate autophagy; atg4 protease; protease integrates; stress ... See more keywords