Active Ras2 in mitochondria promotes regulated cell death in a cAMP/PKA pathway‐dependent manner in budding yeast
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14567
Abstract: Previously, we showed that an aberrant accumulation of activated Ras in mitochondria correlates with an increase in apoptosis. In this article, we show that lack of trehalose‐6P‐synthase, known to trigger apoptosis in Saccharomyces cerevisiae, induces localization… read more here.
Keywords: active ras2; pka pathway; regulated cell; mitochondria ... See more keywords
Hsa_circRNA_0017620 regulated cell progression of non‐small‐cell lung cancer via miR‐520a‐5p/KRT5 axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24347
Abstract: CircRNA is a very important functional RNA that plays an important role in the development and metabolism of cancer. However, the study of circRNA in NSCLC has not been fully elucidated. read more here.
Keywords: hsa circrna; cell; circrna 0017620; 0017620 regulated ... See more keywords
Recent Organic Photosensitizer Designs for Evoking Proinflammatory Regulated Cell Death in Antitumor Immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Small Methods"
DOI: 10.1002/smtd.202201614
Abstract: In the past decades, immunotherapy has achieved a series of clinical successes in the field of cancer. However, existing therapeutic options usually show a low immune response to solid tumors caused by immunosuppressive “cold” tumor… read more here.
Keywords: cell death; immunotherapy; proinflammatory rcd; regulated cell ... See more keywords
Mechanistic connections between mitochondrial biology and regulated cell death.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.03.033
Abstract: The ancient, dynamic, and multifaceted functions of the mitochondrial network are essential for organismal homeostasis and contribute to numerous human diseases. As central hubs for metabolism, ion transport, and multiple macromolecular synthesis pathways, mitochondria establish… read more here.
Keywords: regulated cell; cell; biology; cell death ... See more keywords
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life.
Sign Up to like & getrecommendations! Published in 2023 at "Human reproduction update"
DOI: 10.1093/humupd/dmad005
Abstract: BACKGROUND Regulated cell death is a fundamental component of numerous physiological processes; spanning from organogenesis in utero, to normal cell turnover during adulthood, as well as the elimination of infected or damaged cells throughout life.… read more here.
Keywords: cell death; death; life; regulated cell ... See more keywords
Regulated cell death in cancer: from pathogenesis to treatment
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002239
Abstract: Abstract Regulated cell death (RCD), including apoptosis, pyroptosis, necroptosis, and ferroptosis, is regulated by a series of evolutionarily conserved pathways, and is required for development and tissue homeostasis. Based on previous genetic and biochemical explorations… read more here.
Keywords: cell death; treatment; regulated cell; cancer ... See more keywords
The Antifungal Protein AfpB Induces Regulated Cell Death in Its Parental Fungus Penicillium digitatum
Sign Up to like & getrecommendations! Published in 2020 at "mSphere"
DOI: 10.1128/msphere.00595-20
Abstract: Disease-causing fungi pose a serious threat to human health and food safety and security. The limited number of licensed antifungals, together with the emergence of pathogenic fungi with multiple resistance to available antifungals, represents a… read more here.
Keywords: cell death; medicine; regulated cell; death ... See more keywords
The evolution of regulated cell death pathways in animals and their evasion by pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reviews"
DOI: 10.1152/physrev.00002.2021
Abstract: The coevolution of host-pathogen interactions underlies many human physiological traits associated with protection from or susceptibility to infections. Among the mechanisms that animals utilize to control infections are the regulated cell death pathways of pyroptosis,… read more here.
Keywords: death pathways; cell death; death; evolution ... See more keywords
Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0387
Abstract: Loss of nitric oxide synthase is shown to debilitate cytotoxic T cells in the therapeutic setting. Although nitric oxide is typically characterized as immunosuppressive, these data highlight its key intrinsic role in modulating T-cell tumor… read more here.
Keywords: cell; infiltration tumors; nitric oxide; tumors regulated ... See more keywords
Uncovering molecular mechanisms of regulated cell death in the naked mole rat.
Sign Up to like & getrecommendations! Published in 2021 at "Aging"
DOI: 10.18632/aging.202577
Abstract: The naked mole rat (NMR), Heterocephalus glaber, is the longest-living rodent species, and is extraordinarily resistant to cancer and aging-related diseases. The molecular basis for these unique phenotypic traits of the NMR is under extensive… read more here.
Keywords: regulated cell; death; mole rat; naked mole ... See more keywords
Cellular Senescence and Regulated Cell Death of Tubular Epithelial Cells in Diabetic Kidney Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.924299
Abstract: Cellular senescence is frequently evident at etiologic sites of chronic diseases and involves essentially irreversible arrest of cell proliferation, increased protein production, resistance to apoptosis, and altered metabolic activity. Regulated cell death plays a vital… read more here.
Keywords: cell death; cell; regulated cell; cellular senescence ... See more keywords