MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors
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DOI: 10.1038/s41388-021-01888-1
Abstract: Mini-chromosome maintenance (MCM) proteins are critical components of DNA-replication-licensing factors. MCM8 is an MCM protein that exhibits oncogenic functions in several human malignancies. However, the role of MCM8 in glioblastomas (GBMs) has remained unclear. In… read more here.
Keywords: mcm8; regulated egfr; dna replication; expression ... See more keywords
Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2
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DOI: 10.1158/1078-0432.ccr-17-0605
Abstract: Purpose: Long noncoding RNAs have been implicated in gliomagenesis, but their mechanisms of action are mainly undocumented. Through public glioma mRNA expression data sets, we found that NEAT1 was a potential oncogene. We systematically analyzed… read more here.
Keywords: long noncoding; found neat1; regulated egfr; catenin ... See more keywords