Up-regulated HIF-2α contributes to the Osteoarthritis development through mediating the primary cilia loss.
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DOI: 10.1016/j.intimp.2019.105762
Abstract: BACKGROUNDS Up-regulated HIF-2α (hypoxia induced factor 2) had been demonstrated to contribute to Osteoarthritis (OA) development via inducing the expression of matrix-degrading enzymes. However, the HIF-2α also could promote primary cilia loss through HIF-2α/AURKA (Aurora… read more here.
Keywords: hif; cilia loss; regulated hif; primary cilia ... See more keywords