mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.09.017
Abstract: mTORC1, the major homeostatic sensor and responder, regulates cell catabolism mainly by targeting autophagy. Here, we show that mTORC1 directly controls autophagosome formation via phosphorylation of WIPI2, a critical protein in isolation membrane growth and… read more here.
Keywords: degradation; huwe1; regulated huwe1; mtorc1 ... See more keywords