The biology and inhibition of glucose‐regulated protein 94/gp96
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21915
Abstract: The 94 kDa molecular chaperone, glucose‐regulated protein 94 (Grp94), has garnered interest during the last decade due to its direct association with endoplasmic reticulum (ER) stress and disease. Grp94 belongs to the Hsp90 family of molecular… read more here.
Keywords: inhibition; disease; glucose regulated; disease states ... See more keywords
Erythropoietin-Induced Autophagy Protects Against Spinal Cord Injury and Improves Neurological Function via the Extracellular-Regulated Protein Kinase Signaling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01997-0
Abstract: The objective of this study was to explore the neuroprotective molecular mechanisms of erythropoietin (EPO) in rats following spinal cord injury (SCI). First, a standard SCI model was established. After drug or saline treatment was… read more here.
Keywords: regulated protein; cord injury; signaling pathway; function ... See more keywords
Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.05.016
Abstract: Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a major deubiquitinating enzyme of the nervous system and associated with the development of neurodegenerative diseases. We have previously shown that UCH-L1 is found in tubular and parietal cells… read more here.
Keywords: regulated protein; ubiquitin terminal; required regulated; protein degradation ... See more keywords
Isolation of cypress gibberellin-regulated protein: Analysis of its structural features and IgE binding competition with homologous allergens.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.07.023
Abstract: The presence in cypress pollen of an important allergen, belonging to the gibberellin-regulated protein (GRP) family, has been suggested for many years. However, it has never been isolated and sometimes the homologous peach allergen, Pru… read more here.
Keywords: cypress; regulated protein; pru; gibberellin regulated ... See more keywords
The 150-kDa oxygen-regulated protein (ORP150) regulates proteinuria in diabetic nephropathy via mediating VEGF.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2019.04.014
Abstract: The 150-kDa oxygen-regulated protein (ORP150) belongs to a family of the heat shock protein implicated in the cellular response to environmental stress. Previous data demonstrated that ORP150 regulates the secretion of vascular endothelial growth factor… read more here.
Keywords: mediating vegf; 150 kda; regulated protein; kda oxygen ... See more keywords
Glucose-regulated protein 75 determines ER–mitochondrial coupling and sensitivity to oxidative stress in neuronal cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death Discovery"
DOI: 10.1038/cddiscovery.2017.76
Abstract: The crosstalk between different organelles allows for the exchange of proteins, lipids and ions. Endoplasmic reticulum (ER) and mitochondria are physically linked and signal through the mitochondria-associated membrane (MAM) to regulate the transfer of Ca2+… read more here.
Keywords: regulated protein; glucose regulated; grp75; ca2 ... See more keywords
Glucose-regulated protein 78 substrate-binding domain alters its conformation upon EGCG inhibitor binding to nucleotide-binding domain: Molecular dynamics studies
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22905-6
Abstract: Glucose-regulated protein 78 (GRP78), is overexpressed in glioblastoma, other tumors and during viral and bacterial infections, and so, it is postulated to be a key drug target. EGCG, an ATP-competitive natural inhibitor, inhibits GRP78 effect… read more here.
Keywords: binding domain; inhibitor; regulated protein; nucleotide binding ... See more keywords
Distinct classes and subclasses of antibodies to hemolysin co-regulated protein 1 and O-polysaccharide and correlation with clinical characteristics of melioidosis patients
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48828-4
Abstract: Melioidosis is a tropical infectious disease caused by Burkholderia pseudomallei that results in high mortality. Hemolysin co-regulated protein 1 (Hcp1) and O-polysaccharide (OPS) are vaccine candidates and potential diagnostic antigens. The correlation of classes/subclasses of… read more here.
Keywords: melioidosis patients; regulated protein; characteristics melioidosis; hemolysin regulated ... See more keywords
Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity
Sign Up to like & getrecommendations! Published in 2019 at "Particle and Fibre Toxicology"
DOI: 10.1186/s12989-019-0324-2
Abstract: BackgroundGold nanoparticles (Au-NPs) have extensive applications in electronics and biomedicine, resulting in increased exposure and prompting safety concerns for human health. After absorption, nanoparticles enter circulation and effect endothelial cells. We previously showed that exposure… read more here.
Keywords: regulated protein; cerebral edema; expression; activity ... See more keywords
Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Internal medicine"
DOI: 10.2169/internalmedicine.9783-22
Abstract: Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a… read more here.
Keywords: neuromyelitis optica; optica spectrum; glucose regulated; spectrum disorder ... See more keywords
Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1066185
Abstract: Introduction Post translational modification of proteins plays a significant role in immune recognition. In particular the modification of arginine to citrulline which is mediated by PAD enzymes is increased during cellular stress (autophagy) which permits… read more here.
Keywords: cd4; melanoma; glucose regulated; citrullinated grp78 ... See more keywords