Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways
Sign Up to like & getrecommendations! Published in 2020 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-020-00834-8
Abstract: Chronic hyperglycemia and diabetes lead to impaired cardiac repolarization, K+ channel remodeling and increased arrhythmia risk. However, the exact signaling mechanism by which diabetic hyperglycemia regulates cardiac K+ channels remains elusive. Here, we show that… read more here.
Keywords: nox2 ros; hyperglycemia regulates; camkii; hyperglycemia ... See more keywords
The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aax4826
Abstract: UCHL1 positively regulates cardiac hypertrophy via stabilizing EGFR and highlighting it as a yet unknown therapeutic target. Pathological cardiac hypertrophy leads to heart failure (HF). The ubiquitin-proteasome system (UPS) plays a key role in maintaining… read more here.
Keywords: cardiac hypertrophy; factor receptor; growth factor; epidermal growth ... See more keywords
Adipose Lipolysis Regulates Cardiac Glucose Uptake and Function in Mice under Cold Stress.
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DOI: 10.3390/ijms222413361
Abstract: The heart primarily uses fatty acids as energy substrates. Adipose lipolysis is a major source of fatty acids, particularly under stress conditions. In this study, we showed that mice with selective inactivation of the lipolytic… read more here.
Keywords: regulates cardiac; mice; lipolysis; adipose lipolysis ... See more keywords
Dock10 Regulates Cardiac Function under Neurohormonal Stress
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179616
Abstract: Dedicator of cytokinesis 10 (Dock10) is a guanine nucleotide exchange factor for Cdc42 and Rac1 that regulates the JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) signaling cascades. In this study, we characterized… read more here.
Keywords: stress; cardiac function; dock10; dock10 regulates ... See more keywords