lncRNA‐CIR regulates cell apoptosis of chondrocytes in osteoarthritis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27997
Abstract: Osteoarthritis (OA) is a complex chronic degenerative joint disease involving oxidative stress, inflammation, and apoptosis of chondrocytes. As decoys of micro RNAs, long non‐coding RNAs (lncRNAs) play important roles in various biological processes. This study… read more here.
Keywords: apoptosis chondrocytes; regulates cell; lncrna cir; apoptosis ... See more keywords
Modification of p27 with O‐linked N‐acetylglucosamine regulates cell proliferation in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22490
Abstract: The tumor suppressor p27, which is a member of the Cip/Kip family of Cyclin‐dependent kinase inhibitory proteins (CKIs), controls anti‐proliferative events. The post‐translational addition of O‐GlcNAc to p27 occurs in HEK293T and HCC (hepatocellular carcinoma)… read more here.
Keywords: hepatocellular carcinoma; cell proliferation; regulates cell; p27 ... See more keywords
SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.007
Abstract: The protein arginine methyltransferase 6 (PRMT6) is a coregulator of gene expression by methylation of the histone H3 on arginine 2 (H3R2), H4R3 and H2AR3 [1,2]. PRMT6 is aberrantly expressed in various types of human… read more here.
Keywords: degradation; prmt6; regulates cell; fbxo24 regulates ... See more keywords
PDS5B regulates cell proliferation and motility via upregulation of Ptch2 in pancreatic cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.06.014
Abstract: Pds5b (precocious dissociation of sisters 5B) is involved in both tumorigenesis and cancer progression; however, the functions and molecular mechanisms of Pds5b in pancreatic cancer (PC) are unknown. Several approaches were conducted to investigate the… read more here.
Keywords: regulates cell; cell proliferation; pds5b; pancreatic cancer ... See more keywords
Dnmt3a Regulates T-cell Development and Suppresses T-ALL Transformation
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.89
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic neoplasm resulting from the malignant transformation of T-cell progenitors, and comprises ~15% and 25% of pediatric and adult ALL cases, respectively. It is well-established that activating… read more here.
Keywords: dnmt3a regulates; dnmt3a; regulates cell; development suppresses ... See more keywords
Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29725-3
Abstract: TCR stimulation triggers Ca2+ signals that are critical for T cell function and immunity. Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) were reported in T cells, but their mechanism of… read more here.
Keywords: regulates cell; gated ca2; voltage gated; cav regulates ... See more keywords
PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29930-0
Abstract: Programmed death-1 (PD-1) and its ligand PD-L1 are checkpoint molecules which regulate immune responses. Little is known about their functions in T cell migration and there are contradictory data about their roles in regulatory T… read more here.
Keywords: regulates cell; selectively regulates; transendothelial migration; signaling selectively ... See more keywords
Glucocorticoid signaling regulates cell invasion and migration in the human first‐trimester trophoblast cell line Sw.71
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.12974
Abstract: The development of the placenta and its functions are sensitive to infection and stress, which can activate the hypothalamic‐pituitary‐adrenal axis. Adrenally produced glucocorticoids are the body's primary mediators of the inflammatory and stress response. Although… read more here.
Keywords: regulates cell; glucocorticoid signaling; invasion migration; signaling regulates ... See more keywords
The three‐component system EsrISR regulates a cell envelope stress response in Corynebacterium glutamicum
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13839
Abstract: When the cell envelope integrity is compromised, bacteria trigger signaling cascades resulting in the production of proteins that counteract these extracytoplasmic stresses. Here, we show that the two‐component system EsrSR regulates a cell envelope stress… read more here.
Keywords: component system; cell envelope; system; regulates cell ... See more keywords
A massive machine regulates cell death
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.adg9605
Abstract: Description Structural analysis reveals how the decision to induce apoptotic cell death is regulated Cells are bombarded with signals about their environment, which they integrate to decide an appropriate response. Danger signals elicit the most… read more here.
Keywords: cell death; massive machine; machine regulates; death ... See more keywords
RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.02815-19
Abstract: Control of mRNA localization, stability, turnover, and translation by RNA-binding proteins (RBPs) influences essential processes in all eukaryotes, including signaling by mitogen-activated protein kinase (MAPK) pathways. We describe that in the fission yeast Schizosaccharomyces pombe… read more here.
Keywords: rnc1; kinase; growth; regulates cell ... See more keywords