IRF2 regulates cellular survival and Lenvatinib-sensitivity of hepatocellular carcinoma (HCC) through regulating β-catenin
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101059
Abstract: Highlights • IRF2 and β-catenin are highly expressed in HCC tissues.• IRF2 upregulation of β-catenin promotes HCC cell proliferation.• IRF2 enhances lenvatinib resistance in HCC cells. read more here.
Keywords: hcc; cellular survival; catenin; irf2 regulates ... See more keywords
ATF3 negatively regulates cellular antiviral signaling and autophagy in the absence of type I interferons
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08584-9
Abstract: Stringent regulation of antiviral signaling and cellular autophagy is critical for the host response to virus infection. However, little is known how these cellular processes are regulated in the absence of type I interferon signaling.… read more here.
Keywords: cellular antiviral; antiviral signaling; regulates cellular; absence type ... See more keywords
Cytomegalovirus US28 regulates cellular EphA2 to maintain viral latency
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add1168
Abstract: Cytomegalovirus (CMV) reactivation from latency following immune dysregulation remains a serious risk for patients, often causing substantial morbidity and mortality. Here, we demonstrate the CMV-encoded G protein–coupled receptor, US28, in coordination with cellular Ephrin receptor… read more here.
Keywords: regulates cellular; cytomegalovirus us28; us28 regulates; cellular epha2 ... See more keywords
p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.698565
Abstract: T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant systems, we show that a prominent feature of PD-1-expressing exhausted T cells is the development of cellular… read more here.
Keywords: p16ink4a regulates; senescence expressing; senescence; cellular senescence ... See more keywords