BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22798
Abstract: BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1+/−) developed one and often several BAP1−/− malignancies in their lifetime, mostly malignant… read more here.
Keywords: bap1 regulates; regulates ip3r3; bap1; ca2 flux ... See more keywords