Neuronal activity regulates Matrin 3 abundance and function in a calcium-dependent manner through calpain-mediated cleavage and calmodulin binding
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DOI: 10.1073/pnas.2206217120
Abstract: Significance Here, we define the molecular pathways responsible for regulating the abundance of Matrin 3 (MATR3), an RNA-binding protein with integral ties to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). We show that the… read more here.
Keywords: activity regulates; regulates matrin; abundance; matrin abundance ... See more keywords