TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2019.12.007
Abstract: Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. Combining chronic demyelination paradigms… read more here.
Keywords: regulates microglial; trem2 regulates; cholesterol; metabolism ... See more keywords
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13834
Abstract: Microglial hyperactivation of the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome contributes to the pathogenesis of Parkinson's disease (PD). Recently, neuronally expressed NLRP3 was demonstrated to be a Parkin polyubiquitination substrate and a driver… read more here.
Keywords: parkin regulates; parkinson disease; regulates microglial; microglial nlrp3 ... See more keywords