The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-024-55557-4
Abstract: Energy deprivation and metabolic rewiring of cardiomyocytes are widely recognized hallmarks of heart failure. Here, we report that HEY2 (a Hairy/Enhancer-of-split-related transcriptional repressor) is upregulated in hearts of patients with dilated cardiomyopathy. Induced Hey2 expression… read more here.
Keywords: transcriptional repressor; hey2; repressor hey2; hey2 regulates ... See more keywords
TSG101 negatively regulates mitochondrial biogenesis in axons
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2018770118
Abstract: Significance Mitochondrial dysfunction has been associated with many age-dependent neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease, yet understanding how a neuron maintains a pool of functional mitochondria in sufficient density and location throughout axons… read more here.
Keywords: mitochondrial biogenesis; biogenesis; regulates mitochondrial; mitochondrial number ... See more keywords
Abstract 270: Micu1 Regulates Mitochondrial Structural Integrity and Cristae Function Independent of Mcu Calcium Uptake
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.270
Abstract: MICU1 is a Ca 2+ -sensor regulating the mitochondrial Ca 2+ uniporter channel (mtCU) and mitochondrial Ca 2+ uptake. MICU1 contains two Ca 2+ - binding EF-hand domains and directly interacts with the mtCU pore-forming… read more here.
Keywords: cristae; micos; mcu; regulates mitochondrial ... See more keywords
Prostaglandin F2α regulates mitochondrial dynamics and mitophagy in the bovine corpus luteum
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202301968
Abstract: This study investigates the early effects of PGF2α signaling on mitochondrial dynamics and mitophagy in bovine corpora lutea. Luteolytic mediator PGF2α, via PKC/ERK and AMPK signaling, activates mitochondrial fission and promotes PINK–Parkin mitophagy, placing mitochondria… read more here.
Keywords: prostaglandin regulates; mitochondrial dynamics; regulates mitochondrial; dynamics mitophagy ... See more keywords
Cardiolipin Regulates Mitochondrial Ultrastructure and Function in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13101889
Abstract: Cardiolipin (CL) is a unique, tetra-acylated diphosphatidylglycerol lipid that mainly localizes in the inner mitochondria membrane (IMM) in mammalian cells and plays a central role in regulating mitochondrial architecture and functioning. A deficiency of CL… read more here.
Keywords: function mammalian; cardiolipin regulates; mitochondrial ultrastructure; regulates mitochondrial ... See more keywords
SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106–126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25179707
Abstract: Mitochondrial damage is an early and key marker of neuronal damage in prion diseases. As a process involved in mitochondrial quality control, mitochondrial biogenesis regulates mitochondrial homeostasis in neurons and promotes neuron health by increasing… read more here.
Keywords: damage; mitochondrial biogenesis; n2a cells; regulates mitochondrial ... See more keywords