Abstract 328: Acetylation regulates the oncogenic functions of PRMT5
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-328
Abstract: Protein arginine methyltransferase 5 (PRMT5) is an enzyme responsible for symmetric arginine methylation, which governs multiple crucial cellular events. PRMT5 expression and activity are dysregulated in many malignancies. PRMT5 dynamically shuttles between the cytosol and… read more here.
Keywords: regulates oncogenic; acetylation; functions prmt5; acetylation regulates ... See more keywords
Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-22-0366
Abstract: The dysregulation of developmental and stem cell associated genes is a common phenomenon during cancer development. Around half of acute myeloid leukemia (AML) patients express high levels of HOXA cluster genes and MEIS1. Most of… read more here.
Keywords: directly regulates; regulates oncogenic; acute myeloid; myeloid leukemia ... See more keywords