GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-05-0270
Abstract: The diversion of the β-secretase BACE1 from the endo-lysosomal pathway to recycling endosomes is important in the regulation of amyloid beta production. Here we define BACE1 transport from early to recycling endosomes and identify essential… read more here.
Keywords: recycling endosomes; production; signal dependent; gga1 regulates ... See more keywords
Phospho‐inositide‐dependent kinase 1 regulates signal dependent translation in megakaryocytes and platelets
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14748
Abstract: Regulated protein synthesis is essential for megakaryocyte (MK) and platelet functions, including platelet production and activation. PDK1 (phosphoinositide‐dependent kinase 1) regulates platelet functional responses and has been associated with circulating platelet counts. Whether PDK1 also… read more here.
Keywords: phospho inositide; dependent kinase; inositide dependent; regulates signal ... See more keywords