VPS35 regulates tau phosphorylation and neuropathology in tauopathy
Sign Up to like & getrecommendations! Published in 2019 at "Molecular psychiatry"
DOI: 10.1038/s41380-019-0453-x
Abstract: The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. Deficiency in VPS35 by altering APP/Aβ metabolism has been linked to late-onset… read more here.
Keywords: tau; regulates tau; pathological tau; vps35 ... See more keywords
Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm4295
Abstract: Accumulation of the microtubule-associated protein Tau is linked to neuronal cell death in tauopathies, but how intraneuronal Tau levels are regulated in health and disease remains unclear. Here, we show that conditional inactivation of the… read more here.
Keywords: tau; levels prevents; mouse; numb regulates ... See more keywords