Estradiol up-regulates L-type Ca2+ channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2018.01.019
Abstract: BACKGROUND In long QT syndrome type 2, women are more prone than men to the lethal arrhythmia torsades de pointes. We previously reported that 17β-estradiol (E2) up-regulates L-type Ca2+ channels and current (ICa,L) (∼30%) in… read more here.
Keywords: akt; regulates type; kinase; ca2 ... See more keywords
Duck TRIM29 negatively regulates type I IFN production by targeting MAVS
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1016214
Abstract: The innate immune response is a host defense mechanism that induces type I interferon and proinflammatory cytokines. Tripartite motif (TRIM) family proteins have recently emerged as pivotal regulators of type I interferon production in mammals.… read more here.
Keywords: regulates type; production; ifn; negatively regulates ... See more keywords
Fis Regulates Type III Secretion System by Influencing the Transcription of exsA in Pseudomonas aeruginosa Strain PA14
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.00669
Abstract: Fis is a versatile DNA binding protein in bacteria. It has been demonstrated in multiple bacteria that Fis plays crucial roles in regulating bacterial virulence factors and optimizing bacterial adaptation to various environments. However, the… read more here.
Keywords: transcription; pseudomonas aeruginosa; regulates type; fis regulates ... See more keywords