Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells[S]
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DOI: 10.1194/jlr.m085886
Abstract: In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Angiotensin II, as the main effector of the renin–angiotensin system, decreases glucose-stimulated insulin secretion (GSIS). We examined the effect… read more here.
Keywords: insulin secretion; cholesterol accumulation; angiotensin; regulating abca1 ... See more keywords