Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints.
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DOI: 10.1016/j.tcb.2020.12.001
Abstract: Immune checkpoint inhibitors (ICIs) targeting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) have been hailed as major advances in cancer therapeutics; however, in many cancers response rates remain low. Extensive research… read more here.
Keywords: cell activation; regulating crosstalks; dynamics regulating; signaling dynamics ... See more keywords