Apoptosis signal-regulating kinase 1 inhibition reverses deleterious indoxyl sulfate-mediated endothelial effects.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119267
Abstract: AIMS Indoxyl sulfate (IS), a protein-bound uremic toxin, is implicated in endothelial dysfunction, which contributes to adverse cardiovascular events in chronic kidney disease. Apoptosis signal regulating kinase 1 (ASK1) is a reactive oxygen species-driven kinase… read more here.
Keywords: regulating kinase; inhibition; apoptosis signal; signal regulating ... See more keywords
Probing the Inhibition of Microtubule Affinity Regulating Kinase 4 by N-Substituted Acridones
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-38217-8
Abstract: Microtubule affinity regulating kinase 4 (MARK4) becomes a unique anti-cancer drug target as its overexpression is responsible for different types of cancers. In quest of novel, effective MARK4 inhibitors, some acridone derivatives were synthesized, characterized… read more here.
Keywords: regulating kinase; affinity; kinase; affinity regulating ... See more keywords
Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1468282
Abstract: Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential drug target for several complex diseases including cancer, diabetes and neurodegenerative disorders. Inhibition of MARK4 activity is an appealing therapeutic option to treat… read more here.
Keywords: regulating kinase; kinase mark4; potential inhibitors; affinity regulating ... See more keywords
Abstract 22: Apoptosis Signal-Regulating Kinase 1 (ASK1) is a Novel Master Molecular Switch Controlling Microglia/Macrophage Reactions That Impact Short- and Long-Term Stroke Outcomes
Sign Up to like & getrecommendations! Published in 2019 at "Stroke"
DOI: 10.1161/str.50.suppl_1.22
Abstract: Introduction: Recent studies suggest that the functional status of microglia/macrophages (Mi/MΦ) profoundly impacts stroke outcome. However, the molecular mechanisms regulating Mi/MΦ reactions afte... read more here.
Keywords: kinase ask1; apoptosis signal; ask1 novel; regulating kinase ... See more keywords
Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144652
Abstract: Microtubule affinity regulating kinase 4 (MARK4) regulates the mechanism of microtubules by its ability to phosphorylate the microtubule-associated proteins (MAP’s). MARK4 is known for its major role in tau phosphorylation via phosphorylating Ser262 residue in… read more here.
Keywords: microtubule affinity; affinity; mark4; regulating kinase ... See more keywords
Microtubule affinity regulating kinase (MARK/Par1) isoforms differentially regulate Alzheimer-like TAU missorting and Aβ-mediated synapse pathology
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.346477
Abstract: Importance of TAU protein for dementia syndromes: Dementia currently affects about 55 million people worldwide, with Alzheimer ́s disease (AD) being the most prevalent form. The one crucial pathological hallmark of AD that correlates best… read more here.
Keywords: tau; kinase mark; microtubule affinity; pathology ... See more keywords
Hyperoside alleviates doxorubicin-induced myocardial cells apoptosis by inhibiting the apoptosis signal-regulating kinase 1/p38 pathway
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.15315
Abstract: Background Cardiotoxicity is a side effect of the anthracycline broad-spectrum anti-tumor agent, doxorubicin (DOX). Hyperoside, a flavonoid glycoside extracted from many herbs, has anti-apoptotic and anticancer properties. However, its impact on the alleviation of DOX-induced… read more here.
Keywords: apoptosis signal; dox; signal regulating; regulating kinase ... See more keywords