Inhibition of microRNA-34a Suppresses Epileptiform Discharges Through Regulating Notch Signaling and Apoptosis in Cultured Hippocampal Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02772-x
Abstract: Epilepsy is characterized by recurrent unprovoked seizures and some seizures can cause neuronal apoptosis, which is possible to make contributions to the epilepsy phenotype, impairments in cognitive function or even epileptogenesis. Moreover, many studies have… read more here.
Keywords: apoptosis; notch signaling; epileptiform discharges; regulating notch ... See more keywords
ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway
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DOI: 10.18632/oncotarget.14164
Abstract: In neurons, up-regulation of Notch activity either inhibits neurite extension or causes retraction of neurites. Conversely, inhibition of Notch1 facilitates neurite extension. Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels, which play… read more here.
Keywords: asic1a; notch; neurite growth; notch signaling ... See more keywords
MicroRNA-34a suppresses colorectal cancer metastasis by regulating Notch signaling
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DOI: 10.3892/ol.2017.6444
Abstract: Dysregulation of microRNA (miRNA/miR) expression is causally associated with cancer initiation and progression. However, the precise mechanisms by which dysregulated miRNAs induce colorectal tumorigenesis remain unknown. In the present study, downregulation of miR-34a was identified… read more here.
Keywords: mir 34a; cancer metastasis; colorectal cancer; cancer ... See more keywords