Regulation of Autophagy in Neurodegenerative Diseases by Natural Products.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-4272-5_54
Abstract: Neurodegenerative diseases mainly include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD). It is now found that these diseases may be related to autophagic dysfunction. The mechanism is due to abnormalities in autophagy, which… read more here.
Keywords: natural products; regulation autophagy; autophagy neurodegenerative; neurodegenerative diseases ... See more keywords
The regulation of autophagy by calcium signals: Do we have a consensus?
Sign Up to like & getrecommendations! Published in 2018 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.08.005
Abstract: Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates via vesicular engulfment of cellular materials and culminates in their degradation via lysosomal… read more here.
Keywords: ca2 signals; regulation autophagy; autophagic flux; autophagy ... See more keywords
O-GlcNAc Regulation of Autophagy and α-synuclein Homeostasis; Implications for Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.282
Abstract: Post-translational modification on protein Ser/Thr residues by O-linked attachment of s-N-acetyl-glucosamine (O-GlcNAcylation) is a key mechanism integrating redox signaling, metabolism and stress responses. One of the most common neurodegenerative diseases that exhibit aberrant redox signaling,… read more here.
Keywords: glcnac regulation; regulation autophagy; glcnacylation; protein glcnacylation ... See more keywords
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.10.024
Abstract: Autophagy is a conserved intracellular degradation pathway exerting various cytoprotective and homeostatic functions by using de novo double-membrane vesicle (autophagosome) formation to target a wide range of cytoplasmic material for vacuolar/lysosomal degradation. The Atg1 kinase… read more here.
Keywords: formation; regulation autophagy; atg1 kinase; autophagosome formation ... See more keywords
Regulation of Autophagy by Hepatitis C Virus for Its Replication.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2017.4115
Abstract: Macroautophagy, hereafter autophagy, is a catabolic process that is important for maintaining cellular homeostasis. It can also be used by cells to remove intracellular microbial pathogens. However, the studies on hepatitis C virus (HCV) in… read more here.
Keywords: regulation autophagy; virus replication; hepatitis virus; autophagy hepatitis ... See more keywords
Regulation of autophagy by circular RNAs in rheumatoid arthritis: Potential targets of action
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.14665
Abstract: Previous studies have shown that autophagic pathogenesis of rheumatoid arthritis (RA) is regulated by circular RNAs (circRNAs), which accelerate bone damage by participating in the immune inflammatory response. Therefore, exploring the mechanisms underlying circRNA regulation… read more here.
Keywords: regulation autophagy; autophagy circular; rnas rheumatoid; circular rnas ... See more keywords
Transcriptional Regulation of Autophagy-Related Genes by Sin3 Negatively Modulates Autophagy in Magnaporthe oryzae
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00171-23
Abstract: Autophagy is an evolutionarily conserved metabolic process and is required for the growth and pathogenicity of phytopathogenic fungi. The transcriptional regulators and precise mechanisms of regulating autophagy, as well as whether the induction or repression… read more here.
Keywords: sin3; regulation autophagy; level; transcriptional regulation ... See more keywords
Ubiquitin-mediated regulation of autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-019-0569-y
Abstract: Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade cellular constituents and is often induced under cellular stress conditions to restore cell homeostasis. Another prime degradation pathway in the cells is ubiquitin-proteasome… read more here.
Keywords: ubiquitin mediated; degradation; mediated regulation; regulation autophagy ... See more keywords
Regulation of autophagy gene expression and its implications in cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260631
Abstract: Autophagy is a catabolic cellular process that targets and eliminates superfluous cytoplasmic components via lysosomal degradation. This evolutionarily conserved process is tightly regulated at multiple levels as it is critical for the maintenance of homeostasis.… read more here.
Keywords: gene expression; regulation autophagy; cancer; expression ... See more keywords
Hierarchical regulation of autophagy during adipocyte differentiation
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0250865
Abstract: We previously showed that some adipogenic transcription factors such as CEBPB and PPARG directly and indirectly regulate autophagy gene expression in adipogenesis. The order and effect of these events are undetermined. In this study, we… read more here.
Keywords: autophagy adipocyte; adipocyte differentiation; transcription factors; regulation autophagy ... See more keywords
Liraglutide Attenuates Aβ42 Generation in APPswe/SH-SY5Y Cells Through the Regulation of Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s260160
Abstract: Objective This study aimed to clarify whether liraglutide, a GLP-1 analogue, can ameliorate Aβ pathology through the regulation of autophagy in Alzheimer’s disease (AD) and to explore the related mechanisms thereof. Methods We used SH-SY5Y… read more here.
Keywords: generation; appswe sy5y; sy5y cells; liraglutide attenuates ... See more keywords